ArticleCancer genomics & proteomics
Optimizing Liquid Biopsy: Spike-In Panel Approach for ctDNA Copy Number Variation Analysis.
Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
BACKGROUND/
aimCirculating tumor DNA (ctDNA) testing has emerged as a minimally invasive tool for precision oncology, enabling dynamic monitoring of tumor burden and treatment response. However, commercial ctDNA NGS assays often omit clinically important oncogenes, limiting accurate assessment of copy-number variation (CNV). Amplifications of MATERIALS AND
methodsSpike-in targets were designed with KAPA Target Enrichment Custom Designs and integrated into the Avenio panel. Reference materials (Horizon Structural Multiplex cfDNA Standard, 5% (
resultsMean exon coverage was 698.5 for
conclusionIncorporation of a spike-in panel into the Avenio ctDNA assay enabled reliable detection of high-level
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