A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols.

Christian Ascaso-Alegre, Álvaro Linacero-Gracia, Patricia Ferreira, Raquel P Herrera, Juan Mangas-Sánchez

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Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Christian Ascaso-AlegreInstitute of Chemical Synthesis and Homogeneous Catalysis (ISQCH), Spanish National Research Council (CSIC)-University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.

Álvaro Linacero-GraciaInstitute of Chemical Synthesis and Homogeneous Catalysis (ISQCH), Spanish National Research Council (CSIC)-University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.

Patricia FerreiraDepartment of Biochemistry and Molecular and Cellular Biology and Institute of Biocomputation and Physics of Complex Systems (BIFI, GBsC-CSIC Joint Unit), University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.

Raquel P HerreraInstitute of Chemical Synthesis and Homogeneous Catalysis (ISQCH), Spanish National Research Council (CSIC)-University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.ORCID 0000-0002-5244-9569

Juan Mangas-SánchezDepartment of Organic and Inorganic Chemistry, IUQOEM, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.ORCID 0000-0002-3364-1512

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6 · The paper itself

Abstract

Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-nitro alcohols bearing two stereocenters. Optimization of each step enabled the efficient and selective formation of all four diastereomers with excellent stereoselectivity (up to 97:3 dr and er) and good yields. This work highlights the potential of multicatalytic cascades for the synthesis of stereochemically rich molecules.

Identifiers

PMID41481812

DOI10.1021/acs.orglett.5c05184

PMCPMC12814524

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