Evidence map›Paper›PMID 41481778›Full record

ArticleChemical research in toxicology2026

Impact of Arsenite on Transient and Persistent Histone H3 Modifications and Transcriptional Response.

Tatjana Lumpp, Hassan Hijazi, Sandra Stößer, Eda Tekin, Lara Brunner, Franziska Fischer, Sabine Brugière, Delphine Pflieger, Andrea Hartwig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatjana LumppInstitute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, 76131 Karlsruhe, Germany.
Hassan HijaziUniversity Grenoble Alpes, INSERM, CEA, UA13 BGE, CNRS, CEA, UAR2048, 38000 Grenoble, France.
Sandra StößerInstitute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, 76131 Karlsruhe, Germany.
Eda TekinInstitute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, 76131 Karlsruhe, Germany.
Lara BrunnerInstitute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, 76131 Karlsruhe, Germany.
Franziska FischerInstitute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, 76131 Karlsruhe, Germany.
Sabine BrugièreUniversity Grenoble Alpes, INSERM, CEA, UA13 BGE, CNRS, CEA, UAR2048, 38000 Grenoble, France.
Delphine PfliegerUniversity Grenoble Alpes, INSERM, CEA, UA13 BGE, CNRS, CEA, UAR2048, 38000 Grenoble, France.ORCID 0000-0003-2122-3900
Andrea HartwigInstitute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, 76131 Karlsruhe, Germany.ORCID 0000-0003-3826-3319

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenite-contaminated groundwater poses a major health concern affecting millions of people. Chronic exposure to elevated levels of inorganic arsenic is implicated in carcinogenesis, with impaired DNA repair and dysregulated DNA and histone modifications as key factors. Using human A549 lung carcinoma cells, we investigated the persistence of acute arsenite-induced cellular stress at the epigenetic and transcriptional levels after 24 h of exposure to 1-25 μM NaAsO

Indexed as

ArsenitesHistonesTranscription, GeneticA549 CellsAcetylationHumansMethylationarseniteArsenitesHistones

Identifiers

PMID41481778
PMCPMC12820973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.