Evidence map›Paper›PMID 41481729›Full record

ArticleScience advances2026

Nickel-catalyzed radical relay enabled chemoselective fluoroalkyl-borylation of [1.1.1]propellane under kinetic control.

Yaxing Wu, Xiuling Wang, Yingqi Han, Xiangyu Chen, Ruitong Zhang, Hongmei Qu, Chao Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaxing WuKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China.ORCID 0000-0003-2091-7679
Xiuling WangKey Laboratory of Systems Bioengineering, Ministry of Education, Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Jingnan District, Tianjin 300350, P. R. China.
Yingqi HanKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China.
Xiangyu ChenKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China.ORCID 0009-0003-7562-4942
Ruitong ZhangKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China.ORCID 0009-0000-9804-9336
Hongmei QuKey Laboratory of Systems Bioengineering, Ministry of Education, Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Jingnan District, Tianjin 300350, P. R. China.
Chao ChenKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China.ORCID 0000-0002-7644-0884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, fluoroalkyl-substituted bicyclo[1.1.1]pentanes (BCPs) have attracted considerable attention from the medicinal chemistry community due to their superior physicochemical properties as pharmaceutical bioisosteres of benzene rings. However, related early medicinal research is hampered by a number of challenges, including insufficient and lengthy construction of valuable fluoroalkyl BCP building blocks. Here, we report a general approach to fluoroalkyl-substituted BCP-BPins in a single step using [1.1.1]propellane and economical B

Identifiers

PMID41481729
PMCPMC12758546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.