Evidence map›Paper›PMID 41481715›Full record

ArticleScience advances2026

Integrin inhibition facilitates fibrocartilaginous transformation in connective tissue in osteoarthritis.

Ruiye Bi, Xianni Yang, Haohan Li, Yanjing Zhan, Qing Yin, Han Fang, Ziqian Wang, Binbin Ying, Haopeng Yu, Songsong Zhu

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruiye BiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-8297-9691
Xianni YangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-0179-758X
Haohan LiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-7452-0514
Yanjing ZhanState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0001-9923-6619
Qing YinState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Han FangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-4817-9375
Ziqian WangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-0479-9871
Binbin YingDepartment of Stomatology, The First Affiliated Hospital of Ningbo University, Ningbo, China.ORCID 0000-0002-1851-8049
Haopeng YuWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0003-0525-3157
Songsong ZhuState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0001-7593-3663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a disabling condition with pathological remodeling of different joints, resulting in impaired function of the whole musculoskeletal system in vertebrates. Fibrocartilage has poor self-repair capacity after OA, leading to restricted treatment strategies and unsatisfying clinical efficacy. Recently, we constructed the spatiotemporal multiomic landscape of fibrocartilage and connective tissue in human temporomandibular joint (TMJ)-OA, observing that adjacent connective tissue could transform to fibrocartilage in TMJ-OA. We found that the

Indexed as

Connective TissueFibrocartilageOsteoarthritisAnimalsCollagen Type VDisease Models, AnimalExtracellular MatrixFibroblastsHumansMiceReceptors, VitronectinSwineTemporomandibular JointCollagen Type Vintegrin alphaVbeta5Receptors, Vitronectin

Identifiers

PMID41481715
PMCPMC12758515

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.