Evidence map›Paper›PMID 41481710›Full record

ArticleScience advances2026

Dual-receptor targeting of type I dendritic cells with DNA-scaffolded nanoparticles enhances STING-licensed antitumor immunity.

Deblin Jana, Emilia Herdes, Justin Moustouka, Kayla M Mash, Jingge Chen, Kareem Ebeid, Marwa Sallam, Akram Abbasi, Tejal Desai

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Design Considerations for Potent DNA-Platform-Based Cancer Vaccines.Current opinion in biomedical engineering · 2026
    Article
  2. Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Deblin JanaSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-2157-724X
Emilia HerdesSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0009-0009-8848-7362
Justin MoustoukaSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0009-0003-1622-0171
Kayla M MashDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO 80308, USA.ORCID 0009-0002-3542-7592
Jingge ChenSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-3367-5691
Kareem EbeidSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-8063-5449
Marwa SallamSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0001-9097-4754
Akram AbbasiSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-2877-8204
Tejal DesaiSchool of Engineering, Institute for Biology, Engineering and Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-3409-9208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activating the stimulator of interferon genes (STING) pathway in conventional type I dendritic cells (cDC1s) is crucial for inhibiting solid tumor metastasis. A major hurdle is the cell type-specific delivery of immune agonists. To overcome this, we created a DNA-scaffolded poly(lactic-

Indexed as

Dendritic CellsDNALectins, C-TypeMembrane ProteinsNanoparticlesNeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansMiceReceptors, ImmunologicSTING ProteinClec9a protein, mouseDNALectins, C-TypeMembrane ProteinsReceptors, ImmunologicSting1 protein, mouseSTING Protein

Identifiers

PMID41481710
PMCPMC12758523

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.