Evidence map›Paper›PMID 41481694›Full record

ArticleCirculation research2026

Molecular Symphony of Sympathetic Acceleration: Reframing the Pacemaker Paradigm.

Li Xiao, Wenxuan Cai, Héctor H Valdivia

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Li XiaoCardiovascular Research Center, Department of Medicine, University of Wisconsin-Madison.
Wenxuan CaiCardiovascular Research Center, Department of Medicine, University of Wisconsin-Madison.
Héctor H ValdiviaCardiovascular Research Center, Department of Medicine, University of Wisconsin-Madison.ORCID 0000-0003-1231-6267

Funding

Rational Design from Cryo-EM Structures of High-Affinity Ryanodine Receptor Ligands Based on Natural PeptidesR01HL170144 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Hector H Valdivia · 2023 to 2026
$2.6M
Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasR01HL167195 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado, Hector H Valdivia · 2023 to 2026
$2.4M
NHLBI NIH HHS R01 HL167195NHLBI NIH HHS R01 HL170144
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiac pacemakerEditorialsheart ratehyperpolarization-activated cyclic nucleotide-gated channelsreflexryanodine receptor calcium release channelsarcoplasmic reticulum

Identifiers

PMID41481694
PMCPMC12997170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.