Observational studyBlood transfusion = Trasfusione del sangue
ICU-acquired infections and thrombo-embolic events in critically ill patients receiving platelet transfusion: a prospective multicenter observational study.
Observational study in Blood transfusion = Trasfusione del sangue. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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19 authors.
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Abstract
backgroundPlatelet transfusion is relatively common in patients hospitalized in intensive care units (ICU). Both ICU-acquired infections and thromboembolic events have been reported after platelet transfusion. We sought to explore risk-factors of these complications. MATERIALS AND
methodsWe conducted a ancillary analysis of a multicenter prospective observational study including critically ill patients who received at least one platelet transfusion in one of the 9 participating ICUs. Patients' characteristics were compared according to the occurrence of post platelet transfusion ICU-acquired infections (blood stream infections and ventilator-associated pneumonia) and thromboembolic events. Factors associated with those outcomes were assessed by univariable and multivariable Fine and Gray regression.
resultsOf the 310 included patients, 64 patients (20.6%) and 14 patients (4.5%) experienced at least one ICU-acquired infection and a thromboembolic event after platelet transfusion, respectively. Fifty patients (78.1%) developed blood stream infection (BSI), 32 (50%) experienced ventilator associated pneumonia (VAP) and 18 (28.1%) had both VAP and BSI. Independent risk factors for post platelet transfusion ICU-acquired infection included a platelet count at ICU admission <10 DISCUSSION: In this prospective multicenter study, the risk of hospital-acquired infection after platelet transfusion increased in patients receiving multiple platelet transfusions and with patient severity at ICU admission.
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