Evidence map›Paper›PMID 41481435›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes.

Joydeep Chakraborty, Adhideb Ghosh, Eunice B Awuah, Sally P Stabler, Martha S Field, Regan L Bailey, Patrick J Stover

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joydeep ChakrabortyDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL 32306.ORCID 0000-0002-8804-2920
Adhideb GhoshFunctional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich 8057, Switzerland.ORCID 0000-0002-5160-4571
Eunice B AwuahDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14850.
Sally P StablerDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.
Martha S FieldDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14850.ORCID 0000-0001-7547-5180
Regan L BaileyInstitute for Connecting Nutrition and Health, Florida State University, Tallahassee, FL 32306.
Patrick J StoverDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL 32306.ORCID 0000-0002-7546-3814

Funding

USDA | Agricultural Research Service (ARS) A Systematic Research Approach to Responsive Agriculture for the Advancement of Health
6 · The paper itself

Abstract

Folate-mediated one-carbon metabolism is implicated in several pathologies including neural tube defects (NTDs), cancer, and neurodegenerative disorders, whereas diabetes is associated with NTDs and peripheral neuropathy (PN). The development of peripheral neuropathy was assessed in

Indexed as

Diabetes Mellitus, Type 2Diabetic NeuropathiesFolic AcidNeural Tube DefectsPeripheral Nervous System DiseasesAnimalsDisease Models, AnimalFemaleGanglia, SpinalGlycine HydroxymethyltransferaseMaleMiceMice, KnockoutFolic AcidGlycine HydroxymethyltransferaseShmt1 protein, mousefolate metabolismfolic acidneural tube defectsneuropathyShmt1

Identifiers

PMID41481435
PMCPMC12773702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.