Evidence map›Paper›PMID 41481427›Full record

ArticleGut microbes2026

Jingyu Wang, Fuming Zi, Wu Liu, Chengrui Liu, Zhengfeng Zhang, Leilei Kong, Xuan Xu, Jing Wei, Tingtao Chen, Jian Li

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingyu WangThe Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Fuming ZiThe Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wu LiuThe Department of Cardiovascular Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Chengrui LiuQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhengfeng ZhangThe Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Leilei KongThe Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xuan XuHuankui Academy, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jing WeiNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, China.
Tingtao ChenThe Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0002-0506-8536
Jian LiThe Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0003-0468-1694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence reveals a strong connection between the gut microbiota and cancer. However, the exact role of gut microbiota dysbiosis in multiple myeloma (MM) is poorly understood, and the therapeutic potential of microbiota-targeted interventions represents a promising strategy that demands urgent mechanistic and translational investigation. First, we conducted a comprehensive microbiome-metabolite analysis between MM patients and healthy individuals. The result revealed a marked compositional difference characterized by reduced abundances of butyrate-producing bacteria and diminished butyrate levels in the MM cohort. Subsequent fecal microbiota transplantation demonstrated that the gut microbiota critically modulates MM progression, with healthy donor-derived microbiota reducing the tumor burden and concomitantly elevating serum butyrate. Furthermore, through function-based culturomics screening,

Indexed as

Bone MarrowClostridium butyricumGastrointestinal MicrobiomeMultiple MyelomaProto-Oncogene Proteins c-aktAnimalsButyratesDysbiosisFecal Microbiota TransplantationFemaleHumansMaleMicePhosphatidylinositol 3-KinasesSignal TransductionTh17 CellsButyratesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktbone marrow microenvironmentgut microbiotaMultiple myelomamyeloma bone diseasePI3K/AKT pathway

Identifiers

PMID41481427
PMCPMC12773645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.