Evidence map›Paper›PMID 41481417›Full record

ArticleCell reports2026

Age-independent and targetable transcription factor networks regulating CD8

Paolo S Turano, Elizabeth Akbulut, Hannah K Dewald, Themistoklis Vasilopoulos, Patricia Fitzgerald-Bocarsly, Utz Herbig, Ricardo Iván Martínez-Zamudio

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Paolo S TuranoRutgers-New Jersey Medical School, Center for Cell Signaling, Department of Microbiology, Biochemistry and Molecular Genetics, 205 South Orange Avenue, Newark, NJ, USA.
Elizabeth AkbulutRutgers-New Jersey Medical School, Department of Pathology, Immunology, and Laboratory Medicine, 185 South Orange Avenue, Newark, NJ, USA.
Hannah K DewaldRutgers-New Jersey Medical School, Department of Pathology, Immunology, and Laboratory Medicine, 185 South Orange Avenue, Newark, NJ, USA.
Themistoklis VasilopoulosDepartment of Pharmacology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ, USA.
Patricia Fitzgerald-BocarslyRutgers-New Jersey Medical School, Department of Pathology, Immunology, and Laboratory Medicine, 185 South Orange Avenue, Newark, NJ, USA. Electronic address: bocarsly@njms.rutgers.edu.
Utz HerbigRutgers-New Jersey Medical School, Center for Cell Signaling, Department of Microbiology, Biochemistry and Molecular Genetics, 205 South Orange Avenue, Newark, NJ, USA. Electronic address: herbigut@njms.rutgers.edu.
Ricardo Iván Martínez-ZamudioRutgers-New Jersey Medical School, Center for Cell Signaling, Department of Microbiology, Biochemistry and Molecular Genetics, 205 South Orange Avenue, Newark, NJ, USA; Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ, USA. Electronic address: ricardo.martinezzamudio@rutgers.edu.

Funding

Transcription Factor Network-Mediated Modulation of Transitional Senescence StatesR35GM155447 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Ricardo Ivan Martinez Zamudio · 2024 to 2026
$1.1M
The impact of Alzheimers Disease neuropathology on immune cell senescence in older African AmericansR21AG067368 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI FITZGERALD-BOCARSLY, PATRICIA, HERBIG, UTZ · 2020 to 2021
$663k
NIA NIH HHS R21 AG067368NIGMS NIH HHS R35 GM155447
6 · The paper itself

Abstract

The age-related decline in immunity is accompanied by the accumulation of senescent CD8

Indexed as

AgingCD8-Positive T-LymphocytesCellular SenescenceGene Regulatory NetworksTranscription FactorsAdultAgedFemaleHumansMaleMiddle AgedT-Cell SenescenceTranscription FactorsagingCAR-T cellCD8(+) T cellscellular senescencechromatinCP: ImmunologyCP: Molecular biologyimmunosenescenceimmunotherapyinflammaginginflammationtranscription factor networks

Identifiers

PMID41481417
PMCPMC12856879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.