Evidence map›Paper›PMID 41481276›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Rapid podocyte loss in murine models triggers the formation of podocyte-parietal epithelial cell intercellular bridges.

Nina Cintron Pregosin, Yiqing Guo, Emily T Dang, Nehaben A Gujarati, Monica P Revelo, Fatima Sheikh, Randolph A Hennigar, David J Salant, Vivette D D'Agati, Sandeep K Mallipattu

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Making a portal for podocyte-parietal cell communication in glomerular injury.American journal of physiology. Renal physiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nina Cintron PregosinDivision of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, United States.ORCID 0000-0003-3700-1560
Yiqing GuoDivision of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, United States.ORCID 0000-0001-5437-3433
Emily T DangDivision of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, United States.
Nehaben A GujaratiDivision of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, United States.
Monica P ReveloDepartment of Pathology, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0002-5746-408X
Fatima SheikhDivision of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, United States.
Randolph A HennigarDepartment of Pathology, Stony Brook University, Stony Brook, New York, United States.
David J SalantDivision of Nephrology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.ORCID 0000-0002-3866-3120
Vivette D D'AgatiDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States.ORCID 0000-0001-7760-6965
Sandeep K MallipattuDivision of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, United States.ORCID 0000-0002-6324-7807

Funding

Mechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathiesR01DK121846 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI HE, JOHN CIJIANG, MALLIPATTU, SANDEEP K · 2020 to 2024
$2.7M
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM127253 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI TSIRKA, STYLIANI-ANNA (STELLA) E · 2018 to 2022
$689k
Investigating podocyte-parietal epithelial cell communication through intercellular bridges in kidney diseaseF31DK138751 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI CINTRON PREGOSIN, NINA · 2024 to 2024
$41k
BLRD VA I01 BX003698Dialysis Clinics (DCI) DCIHHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK112984HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK121846HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) F31DK138751HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) T32GM127253NIDDK NIH HHS R01 DK121846U.S. Department of Veterans Affairs (VA) 1I01BX005300U.S. Department of Veterans Affairs (VA) I01BX003698
6 · The paper itself

Abstract

Podocytes are highly specialized, terminally differentiated visceral epithelial cells that are critical for the maintenance of the glomerular filtration barrier. In subtypes of glomerulonephritis and focal segmental glomerulosclerosis (FSGS), injured podocytes trigger the activation and proliferation of neighboring parietal epithelial cells (PECs) which line Bowman's capsule. Mechanisms by which injured podocytes trigger the activation of PECs remain poorly understood. In three independent murine models of proliferative glomerulopathy, we observed that rapid podocyte loss triggered the formation of novel intercellular bridges (or tunneling nanotubes) extending between podocytes and PECs. Immunofluorescence staining of a coculture of mouse podocytes and PECs also revealed the presence of vesicle-like structures within intercellular bridges. In addition, these vesicle-like structures stained positive for Ras-related protein Rab-11A (RAB11A), a RabGTPase involved in the regulation of vesicle transport, and cytoplasmic dynein 1 heavy chain 1, a critical motor protein involved in cargo transport. Finally, we identified intercellular bridges in human kidney biopsies with subtypes of glomerulonephritis and collapsing FSGS, suggesting relevance to human disease.

Indexed as

Cell CommunicationEpithelial CellsGlomerulonephritisGlomerulosclerosis, Focal SegmentalPodocytesAnimalsBowman CapsuleCell ProliferationCells, CulturedCoculture TechniquesDisease Models, AnimalHumansMiceMice, Inbred C57BLrab GTP-Binding Proteinsrab GTP-Binding ProteinscrescentsFSGSintercellular bridgeparietal epithelial cellpodocytetunneling nanotube

Identifiers

PMID41481276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.