Evidence map›Paper›PMID 41481152›Full record

ArticleACS applied materials & interfaces2026

Biocompatible, Ion-Conductive Hydrogel-Filled Nerve Conduit for Peripheral Nerve Regeneration.

Joyce Huang, Jing Tian, Tzu Chun Chung, Sam Denton, Youchao Teng, Kun-Wei Yeh, Stephanie K Seidlits, Nasim Annabi, Song Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joyce HuangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-9729-0088
Jing TianDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, United States.
Tzu Chun ChungDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, United States.
Sam DentonDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, United States.
Youchao TengDepartment of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Kun-Wei YehDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, United States.
Stephanie K SeidlitsDepartment of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, United States.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0003-1879-1202
Song LiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-4760-8828

Funding

Multimodal wireless electrical stimulation for tissue regenerationR01NS126918 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Song Li, John Rogers · 2022 to 2026
$2.4M
Mechanopriming for cell engineeringR01NS130677 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Song Li · 2023 to 2026
$2.1M
NINDS NIH HHS R01 NS126918NINDS NIH HHS R01 NS130677
6 · The paper itself

Abstract

Peripheral nerve injury can result in a loss of sensation and muscle control. Native axon regeneration rates are insufficient to bridge a large gap due to severe damage, leading to a permanent loss of function. Contemporary use of autografts as a treatment, while effective, is limited by donor-site morbidity. Conductive nerve guides can provide mechanical support for regenerating axons, while electrical conductivity provides bioelectrical cues. However, conventional materials used to provide electrical conductivity to hydrogels are not biodegradable and can induce inflammation, which can further impede regeneration. To address these issues, a biodegradable conductive hydrogel containing choline-based bioionic liquid (BioIL) was designed to bridge large nerve gaps and support native axon regeneration. Choline, a small molecule precursor of various biomolecules, combined with a gelatin-based hydrogel, creates a biodegradable and resorbable hydrogel. Conjugation of BioIL to a gelatin methacrylol (GelMA) hydrogel, followed by saline submersion, imparted an ionic conductivity to the hydrogel. Ion-conductive GelMA/BioIL hydrogels supported the myelination function of Schwann cells and the axon outgrowth from dorsal root ganglia

Indexed as

Biocompatible MaterialsHydrogelsNerve RegenerationPeripheral Nerve InjuriesAnimalsAxonsCholineElectric ConductivityGanglia, SpinalGelatinMaleRatsRats, Sprague-DawleySchwann CellsBiocompatible MaterialsCholineGelatinHydrogelsbiomaterialshydrogelion-conductionionic liquidsnerve regenerationperipheral nerve injury

Identifiers

PMID41481152
PMCPMC13087695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.