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The moderation effect of remnant cholesterol for linking cerebrospinal fluid interleukin 10 to blood pressure.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
BackgroundInflammation is a key component in the pathophysiology of hypertension, in which proinflammatory cytokines interleukin (IL) 1β and IL6 and anti-inflammatory cytokines IL4 and IL10 are involved. Elevated remnant cholesterol (RC) level has emerged as an independent risk factor of incident hypertension, surpassing conventional risk factors based on its strength. Additionally, it has a higher penetration into the arterial wall than conventional lipids and induces arterial wall and systemic inflammations.ObjectiveThis study aimed to investigate the association between cerebrospinal fluid (CSF) ILs, blood pressure (BP), and RC and examine the moderation effects of RC on the relationship between ILs and BP.MethodsThis cross-sectional study included participants (mean age: 31.76 ± 10.22 years) who were divided into RC < 0.8 mmol/L (n = 81) and RC ≥ 0.8 mmol/L (n = 104) groups. BP was measured on the morning before CSF collection, and CSF IL levels were analyzed using ELISA. The linear regression models were constructed to estimate the moderation of RC on the relationship between ILs and BP.ResultsRC may play a moderation role in the relationship between IL10 and BP (R
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