Evidence map›Paper›PMID 41480773›Full record

ArticleThe Journal of clinical investigation2026

Germline inactivation of tumor suppressor BAP1 is associated with white spotting.

Ching-Ni Njauw, Zhenyu Ji, David I Latoni, Jose Mari Villa-Gonzalez, Shelley McCormick, Raj Kumar, Dmitrii Usoltsev, Mykyta Artomov, Boyi Gan, Hensin Tsao

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ching-Ni NjauwWellman Center for Photomedicine, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.
Zhenyu JiWellman Center for Photomedicine, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.
David I LatoniDepartment Dermatology, Univ Puerto Rico School of Medicine, San Juan, Puerto Rico.
Jose Mari Villa-GonzalezWellman Center for Photomedicine, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.
Shelley McCormickMass General Brigham Cancer Institute, Boston, Massachusetts, USA.
Raj KumarDivision Hematology/Oncology, Department Medicine, MGH, Boston, Massachusetts, USA.
Dmitrii UsoltsevThe Steve and Cindy Rasmussen Institute for Genomic Medicine, and Dept Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Mykyta ArtomovThe Steve and Cindy Rasmussen Institute for Genomic Medicine, and Dept Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Boyi GanDepartment Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USA.
Hensin TsaoWellman Center for Photomedicine, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.

Funding

Tumor hypoxia promotes acquired resistance to radiation through ferroptosis inhibitionU54CA274220 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Steven Hsesheng Lin · 2022 to 2026
$8.4M
Targeting SLC7A11-induced nutrient dependency in cancer: mechanisms and preclinical translationR01CA244144 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GAN, BOYI · 2020 to 2024
$2.1M
Targeting ferroptosis in cancer therapyR01CA269646 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Boyi Gan · 2023 to 2026
$2.0M
Targeting ferroptosis in radioresistance in lung cancer: mechanisms and preclinical translationR01CA247992 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GAN, BOYI · 2021 to 2025
$1.9M
NCI NIH HHS R01 CA244144NCI NIH HHS R01 CA247992NCI NIH HHS R01 CA269646NCI NIH HHS U54 CA274220
6 · The paper itself

Abstract

Inherited BAP1 mutations cause melanoma and other cancers and can also lead to white hair patches or skin spots due to pigment cell loss.

Indexed as

Germ-Line MutationTumor Suppressor ProteinsUbiquitin ThiolesteraseFemaleHumansMaleMelanomaSkin NeoplasmsBAP1 protein, humanTumor Suppressor ProteinsUbiquitin ThiolesteraseDermatologyGenetic diseasesGeneticsMelanomaSkin

Identifiers

PMID41480773
PMCPMC12721880

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.