Evidence map›Paper›PMID 41480768›Full record

ReviewThe Journal of clinical investigation2026

Cardiovascular complications of pregnancy.

Yijun Yang, Jennifer Lewey, Zoltan Arany

Abstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yijun YangCardiovascular Institute, and.
Jennifer LeweyDivision of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Zoltan AranyCardiovascular Institute, and.

Funding

Branched chain amino acids in heart failureR01HL152446 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Zoltan P Arany · 2020 to 2026
$3.7M
Evaluating risk of diagnostic delay in peripartum cardiomyopathyR01HL173331 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Lewey · 2025 to 2026
$1.2M
NHLBI NIH HHS R01 HL152446NHLBI NIH HHS R01 HL173331
6 · The paper itself

Abstract

The maternal cardiovascular system undergoes dramatic remodeling in response to the stresses of pregnancy. Although in most cases these changes are temporary and well tolerated, in others they can give rise to complications, including cardiomyopathy, coronary artery disease, and hypertensive cardiovascular disease. Despite an increasing number of preclinical models to study these diseases, specific treatments for any of these pregnancy complications are lacking. As the maternal mortality rate is rising in the United States, it is critical to understand the molecular mechanisms driving cardiovascular changes during pregnancy, and the pathology that can result.

Indexed as

Pregnancy Complications, CardiovascularAnimalsCardiomyopathiesCoronary Artery DiseaseFemaleHumansMaternal MortalityPregnancy

Identifiers

PMID41480768
PMCPMC12721902

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.