Evidence map›Paper›PMID 41480735›Full record

ArticlePsychological medicine2026

Negative association between cognitive functioning and antipsychotic D

Priscilla P Oomen, Shiral S Gangadin, Lieuwe de Haan, Franciska de Beer, Oda E Beune, Doris A D Oostendorp, Marieke J H Begemann, Nynke Boonstra, Martijn Kikkert, Sanne Koops and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Priscilla P OomenBehavioral Science Institute (BSI), https://ror.org/016xsfp80Radboud University Nijmegen, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0001-8430-0905
Shiral S GangadinCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-0084-8226
Lieuwe de HaanDepartment of Psychiatry, https://ror.org/05grdyy37Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Franciska de BeerCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Oda E BeuneCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Doris A D OostendorpCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0009-0009-9120-7544
Marieke J H BegemannCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-6448-2799
Nynke Boonstrahttps://ror.org/026xbkx09NHL Stenden University of Applied Sciences, Leeuwarden, The Netherlands.
Martijn KikkertDepartment of Research, Arkin Mental Health Care, Amsterdam, The Netherlands.
Sanne KoopsCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Wim VelingDepartment of Psychiatry, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-1364-9779
Iris E C SommerCenter for Clinical Neuroscience and Cognition, https://ror.org/03cv38k47University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Funding

ZonMw 636340001ZonMw 80-84800-98-41015
6 · The paper itself

Abstract

backgroundEvidence regarding the effects of antipsychotic medication on cognitive functioning after a first-episode psychosis (FEP) remains inconclusive. This study examined whether dopamine D

methods278 remitted FEP participants from the HAMLETT-trial were included. Cognitive functioning was assessed with the Brief Assessment of Cognition in Schizophrenia, 3-6 months after remission. D

resultsD

conclusionsThe current findings underscore the importance of antipsychotic D

Indexed as

Antipsychotic AgentsCognitionCognitive DysfunctionDopamine D2 Receptor AntagonistsPsychotic DisordersReceptors, Dopamine D2SchizophreniaAdolescentAdultFemaleHumansMaleYoung AdultAntipsychotic AgentsDopamine D2 Receptor AntagonistsDRD2 protein, humanReceptors, Dopamine D2antipsychotic medicationcognitiondopamine D2 affinitypsychosisschizophrenia

Identifiers

PMID41480735
PMCPMC13092990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.