ArticleNeuroImmune pharmacology and therapeutics2025
Maternal opioid use is associated with altered placental bacterial DNA and activation of immune-apoptotic pathways.
Article in NeuroImmune pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Opioid use during pregnancy is associated with adverse perinatal outcomes, but its effects on placental biology are not well understood. Because the placenta plays a vital role in fetal development and immune regulation, we examined how maternal opioid exposure influences microbial DNA signatures and immune gene expression in the placenta. Methods: Placentas from opioid-exposed and control C57 BL/6 female mice were analyzed through 16S rRNA gene sequencing, bulk RNA sequencing and pathway enrichment analysis. Results: Opioid-exposed placentas showed altered microbial DNA profiles, including increased α-diversity and enrichment of Conclusions: Maternal opioid exposure may disrupt placental microbial and immune environments, potentially leading to structural compromise through immune-mediated cellular apoptosis.
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