ArticlePatient preference and adherence2025
A Mediation Model of Medication Literacy and Adherence in Type 2 Diabetes During Hospital-Home Transition.
Article in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The hospital-home transition is a high-risk period for medication management in patients with type 2 diabetes mellitus (T2DM). While bivariate relationships among medication literacy, beliefs, self-efficacy, and adherence have been explored, the integrated mediating mechanisms during this phase remain unclear. This study examined these interrelationships, focusing on the serial mediation beliefs and self-efficacy between literacy and adherence. Patients and Methods: A cross-sectional study enrolled 315 T2DM patients at discharge from a tertiary hospital in Dongguan, China, between August 2022 and October 2023. Data were collected using validated scales, including the Chinese version of the Medication Literacy Questionnaire, the Beliefs about Medicines Questionnaire-Specific, the Self-efficacy for Appropriate Medication Use Scale, and the Morisky Medication Adherence Scale-8. Data analysis was performed using SPSS 26.0 and the PROCESS macro. The study received ethical approval, and all participants provided informed consent. Results: Patients demonstrated moderate medication literacy (4.05±1.49) and medication adherence (6.35±1.27), held stronger necessity beliefs, and reported high self-efficacy (31.19±4.29). Significant correlations were observed between medication literacy, concern beliefs, self-efficacy, and medication adherence (all Conclusion: In conclusion, this study reveals that medication literacy influences adherence in T2DM patients through a sequential psychological pathway: by alleviating concern beliefs, which in turn strengthens self-efficacy. This serial mediation mechanism underscores that effective interventional strategies must extend beyond knowledge dissemination to concurrently address patients' specific concerns and bolster their management confidence, thereby offering a multi-faceted approach to improve adherence during the vulnerable hospital-home transition.
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