Evidence map›Paper›PMID 41480554›Full record

ArticleFrontiers in medicine2025

Cryopreserved exosomes derived from hypoxic Wharton's jelly mesenchymal stromal cells enhance fibroblast proliferation, upregulate COL1A2 expression, and mitigate senescence.

Carolina Quintero-Gil, Wendy Jaraba-Alvarez, Juan P Franco-Salazar, Yurany Blanquiceth, Ferley A Bedoya-Guzmán, Sofía Ortiz-Tamayo, Natalia Quiroz-Correa, Vanesa Sanchez-Giraldo, Karolynn Halpert, Héctor Ortega-Arellano

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carolina Quintero-Gil *BioXtech, Medellín, Colombia.
Wendy Jaraba-Alvarez *BioXcellerator, Medellín, Colombia.
Juan P Franco-SalazarBioXtech, Medellín, Colombia.
Yurany BlanquicethBioXtech, Medellín, Colombia.
Ferley A Bedoya-GuzmánBioXtech, Medellín, Colombia.
Sofía Ortiz-TamayoBioXtech, Medellín, Colombia.
Natalia Quiroz-CorreaBioXtech, Medellín, Colombia.
Vanesa Sanchez-GiraldoBioXtech, Medellín, Colombia.
Karolynn HalpertBioXtech, Medellín, Colombia.
Héctor Ortega-ArellanoBioXtech, Medellín, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) and their exosomes support regeneration by modulating inflammation and promoting tissue repair. Hypoxic preconditioning enhances the regenerative potential of MSCs by enriching their secretome with trophic and immunomodulatory factors. This study evaluated the biological effects of cryopreserved exosomes from hypoxia-conditioned Wharton's Jelly MSCs (WJ-MSCs) on human dermal fibroblasts. WJ-MSCs were cultured under hypoxic conditions (5% O₂, 5% CO₂), and exosomes were isolated, characterized and cryopreserved. The initial preparation contained 1.5 × 10

Indexed as

cellular senescenceCOL1A2 expressionexosomesfibroblast proliferationhypoxic preconditioningmesenchymal stromal cellsregenerative medicine

Identifiers

PMID41480554
PMCPMC12753964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.