Evidence map›Paper›PMID 41480538›Full record

ArticleFrontiers in medicine2025

Exploring potential imaging biomarkers for ischemic retinal vein occlusion: insights from fundus autofluorescence and optical coherence tomography.

Zixun Wang, Jun Zhou, Xiaoxue Hu, Jingjie Ding, Xiaoling Zhang, Ruihua Wei, Xiuhong Qin, Zhiqing Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zixun WangTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Jun Zhou *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiaoxue HuWuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jingjie DingTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiaoling ZhangHandan Eye Hospital (The Third Hospital of Handan), Hebei, China.
Ruihua Wei *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiuhong Qin *The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Zhiqing Li *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate the characteristics of macular edema observed by fundus autofluorescence (FAF) and to analyze noninvasive indicators of ischemia in retinal vein occlusion (RVO) through FAF or optical coherence tomography (OCT). We specifically report a newly recognized FAF-OCT mismatch in ischemic RVO, in which CME is not detectable on FAF. Methods: This study included 74 participants. 49 eyes of 49 patients with RVO and 25 healthy control eyes were included in the study. All patients underwent a complete ophthalmologic examination and were evaluated with FAF, fundus fluorescein angiography (FFA), and OCT. The optical intensities of the inner and outer retinal layers were measured using ImageJ software. Results: Of 49 eyes in RVO patients, FAF imaging showed typical Cystoid macular edema (CME) with hyperautofluorescence in non-ischemic RVO patients (69.57%) and in ischemic RVO patients (26.92%, Conclusion: CME in patients with ischemic RVO is less easily detectable on FAF compared to patients with non-ischemic RVO. This lack of correspondence may provide insight into the type of RVO. We conclude that the presence of DRIL, a p-MLM sign, impairment of the integrity of the external limiting membrane (ELM), and decreased optical intensity or integrity of the ellipsoid zone and RPE can serve as effective indicators of ischemia in RVO patients.

Indexed as

disorganization of retinal inner layersfundus autofluorescenceoptical coherence tomographyprominent middle-limiting membraneretinal vein occlusion

Identifiers

PMID41480538
PMCPMC12755151

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