ArticleWorld journal of stem cells2025
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Article in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Potentials of Stem Cell-Derived Exosomal MicroRNAs in Ferroptosis Modulation: Molecular Insights into Hepatoprotection, Neuroprotection, Cardioprotection, Renoprotection and Pulmonoprotection.Stem cell reviews and reports · 2026Review
- Curcumin-preconditioned bone marrow mesenchymal stem cell exosomes ameliorate postmenopausal osteoporosis by activating mitophagy in osteoblast-lineage cells.Frontiers in cell and developmental biology · 2026Article
- The Versatile Roles of Exosomes in Neurodegenerative Disorders: From Pathological Mechanism and Diagnostic Biomarkers to Therapeutic Application.Drug design, development and therapy · 2026Review
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Authors and funding
14 authors.
Funding
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Abstract
backgroundEmerging evidence indicates that hypoxic preconditioning boosts the antioxidant and anti-apoptotic capacities of mesenchymal stem cell-derived exosomes; however, the specific mechanisms remain incompletely elucidated. This study explored the impact of hypoxia-preconditioned mesenchymal stem cell-derived exosomes (hypo-Exos)
aimTo determine whether and how hypoxic preconditioning augments the cardioprotective efficacy of hypo-Exos against oxidative stress-induced cardiomyocyte apoptosis.
methodsH9C2 cardiomyocytes were treated with hydrogen peroxide (H
resultsHypo-Exos significantly enhanced cell viability, reduced oxidative stress, and inhibited apoptosis of cardiomyocytes. Hypoxic preconditioning significantly increased the expression of exosomal miR-486-5p, which directly targeted the phosphatase and tensin homolog. Additionally, hypo-Exos markedly activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Moreover, deletion of miR-486-5p in hypo-Exos counteracted the anti-apoptotic effects and suppressed PI3K/Akt pathway activation.
conclusionHypoxic preconditioning augments anti-apoptotic properties of exosomes, primarily
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