ArticleBreast cancer (Dove Medical Press)2025
Inavolisib-Based Therapy for PIK3CA-Mutated Advanced Male Breast Cancer: A Cost-Effectiveness Analysis.
Article in Breast cancer (Dove Medical Press), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
Background: The Phase III INAVO120 trial established inavolisib-based therapy as a superior first-line treatment for PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer, a finding of particular importance for the historically underrepresented male population with high unmet need. Methods: A lifetime Markov model was developed from a US payer perspective to evaluate the cost-effectiveness of inavolisib plus palbociclib and fulvestrant versus placebo plus palbociclib and fulvestrant in men with PIK3CA-mutated advanced breast cancer. Primary outcomes were life-years (LYs), quality-adjusted life-years (QALYs), and the incremental cost-effectiveness ratio (ICER). Results: The inavolisib group provided an additional 1.23 LYs and 0.69 QALYs compared to the placebo group, resulting in an ICER of $886,440 per QALY. One-way sensitivity analysis identified the price of inavolisib as the primary driver of the ICER. Probabilistic sensitivity analysis showed a 0% probability of inavolisib being cost-effective at a willingness-to-pay threshold of $150,000 per QALY. Conclusion: Inavolisib-based therapy is not cost-effective for treating PIK3CA-mutated advanced male breast cancer at its current price. Significant price reductions or adjustments to value assessment frameworks are required to ensure equitable access for this underserved population.
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