ArticleFrontiers in endocrinology2025
Association between intrinsic capacity, changes in intrinsic capacity, and cardiometabolic multimorbidity: results from three prospective cohort studies.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of Changes in Intrinsic Capacity With Cognitive Decline and Dementia: A Prospective Cohort Study.Neurology · 2026Article
- The joint association of intrinsic capacity and physical activity with cardiovascular risk in older adults: evidence from four longitudinal cohorts.BMC geriatrics · 2026Article
- Sleep duration, sleep quality, and daytime napping in relation to incident cardiometabolic multimorbidity across three national aging cohorts: a prospective, interpretable machine learning study.Frontiers in nutrition · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intrinsic capacity (IC)is closely associated with cardiometabolic health in middle-aged and older adults. The purpose of this study was to determine the associations of baseline IC, cumulative IC scores, and their dynamic changes with the risk of incident cardiometabolic multimorbidity (CMM). Methods: Using data from three prospective cohorts, the China Health and Retirement Longitudinal Study (CHARLS), the English Longitudinal Study of Ageing (ELSA), and the Health and Retirement Study (HRS), participants who met the eligibility criteria were included in this study. Kaplan-Meier curves and Cox models analyzed risk trends and associations. Results: A total of 11,916 participants were included based on the inclusion and exclusion criteria. At baseline, the risk of CMM in the injured group was significantly higher than that in the non-injured group(Pooled: HR = 1.40, 95% CI 1.30-1.52, Conclusions: IC and its changes relate to CMM risk. Even with IC improvement, risk remains higher than in those with intact IC. Precise strategies to delay IC decline and individualized interventions are needed for CMM control.
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