Evidence map›Paper›PMID 41480321›Full record

ReviewWorld journal of gastroenterology2025

Molecular links between inflammatory bowel disease and Alzheimer's disease through immune signaling and inflammatory pathways.

Siva Sundara Kumar Durairajan, Abhay Kumar Singh, Shahitha M Sulaiman, Supriti Patnaik, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, Balachandar Vellingiri, Chuan-Bin Yang, Leonard L Williams

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siva Sundara Kumar DurairajanMolecular Mycology and Neurodegenerative Disease Research Laboratory, Department of Microbiology, Central University of Tamil Nadu, Tiruvarur 610005, India.
Abhay Kumar SinghMolecular Mycology and Neurodegenerative Disease Research Laboratory, Department of Microbiology, Central University of Tamil Nadu, Tiruvarur 610005, India.
Shahitha M SulaimanDepartment of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur 610005, Tamil Nadu, India.
Supriti PatnaikMolecular Mycology and Neurodegenerative Disease Research Laboratory, Department of Microbiology, Central University of Tamil Nadu, Tiruvarur 610005, India.
Senthilkumar KrishnamoorthiMr. & Mrs Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.
Ashok IyaswamyMr. & Mrs Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.
Balachandar VellingiriDepartment of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda 151401, Punjab, India.
Chuan-Bin YangThe First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China.
Leonard L WilliamsCenter for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, The North Carolina Research Campus, Kannapolis, NC 28081, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), has been increasingly associated with the progression of neurodegenerative disorders, particularly Alzheimer's disease (AD). Emerging data from population-based meta-analyses and

Indexed as

Alzheimer DiseaseColitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesAmyloid beta-PeptidesAnimalsAnti-Inflammatory AgentsBrainBrain-Gut AxisDisease Models, AnimalDisease ProgressionDysbiosisGastrointestinal MicrobiomeHumansInflammationSignal TransductionAmyloid beta-PeptidesAnti-Inflammatory AgentsAlzheimer’s diseaseAmyloidogenesisGut-brain axisImmune signalingInflammatory bowel diseaseInflammatory pathwaysTherapeutics

Identifiers

PMID41480321
PMCPMC12754235

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.