Evidence map›Paper›PMID 41480318›Full record

ArticleWorld journal of gastroenterology2025

Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury.

Yi-Fan Chen, Ze-Tian Wang, Jian Zhao, Jian-Guo Tang, Bai-Yin Zhang

Abstract read
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In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi-Fan ChenDepartment of Trauma-Emergency and Critical Care Medicine Center, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Ze-Tian WangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200240, China.
Jian ZhaoDepartment of Emergency, Shanghai Tenth People's Hospital, Shanghai 200072, China.
Jian-Guo TangDepartment of Trauma-Emergency and Critical Care Medicine Center, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Bai-Yin ZhangDepartment of Trauma-Emergency and Critical Care Medicine Center, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China. boyinercheung@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis-induced intestinal injury disrupts barrier function and exacerbates systemic inflammation, contributing to high mortality.

aimTo investigate the mechanism by which sphinganine protects against sepsis-induced intestinal injury, focusing on macrophage polarization and toll like receptor 2 (TLR2)/nuclear factor kappa-B (NF-κB) signaling.

methodsA cecal ligation and puncture sepsis model was established in mice (

resultsSphinganine significantly reduced serum levels of DAO (

conclusionSphinganine protects against sepsis-induced intestinal injury by inhibiting TLR2/NF-κB signaling, modulating macrophage polarization toward the M2 phenotype, and preserving intestinal barrier integrity.

Indexed as

Intestinal MucosaMacrophagesSepsisSphingosineAnimalsCell PolarityCytokinesDisease Models, AnimalHumansMacrophage ActivationMaleMiceMice, Inbred C57BLMolecular Docking SimulationNF-kappa BProteomicsCytokinesNF-kappa BSphingosineTlr2 protein, mouseToll-Like Receptor 2Intestinal injuryMacrophage polarizationSepsisSphinganineToll like receptor 2/nuclear factor kappa-B

Identifiers

PMID41480318
PMCPMC12754252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.