Evidence map›Paper›PMID 41480306›Full record

ArticleIndian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India2025

Impact of Hyaluronic Acid Lip Filling on the Electromyographic Activity of the Orbicularis Oris Muscle in Adult Women.

Nicole Barbosa Bettiol, Selma Siéssere, Mirella Milla Marino, Laís Valencise Magri, Jardel Francisco Mazzi-Chaves, Paulo Batista de Vasconcelos, Alice Helena de Lima Santos Cardoso, Thamyres Branco, Isabela Hallak Regalo, Simone Cecilio Hallak Regalo and 1 more

Abstract read
In one paragraph

Article in Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Analysis of Lip Pressure and Quality of Life Following Gummy Smile Treatment.Journal of dental research, dental clinics, dental prospects · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicole Barbosa BettiolDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Selma SiéssereDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Mirella Milla MarinoDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Laís Valencise MagriDepartment of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Jardel Francisco Mazzi-ChavesDepartment of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Paulo Batista de VasconcelosDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Alice Helena de Lima Santos CardosoDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Thamyres BrancoDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Isabela Hallak RegaloDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Simone Cecilio Hallak RegaloDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
Marcelo PalinkasDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-3445-8154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The rising use of orofacial harmonization highlights the importance of the lip area, closely linked to the orbicularis oris muscle. This longitudinal study assessed the electromyographic (EMG) activity of the upper and lower orbicularis oris muscle in adult women following hyaluronic acid lip filling. Materials and Methods: Twenty-two adult women, with a mean age of 35.4 ± 12.3 years, were included. EMG was measured during rest, cheek inflation tasks (concurrently and alternately), lip protrusion and compression, and before, 30, and 60 days after lip filling. Differences were significant using Results: Significant EMG differences were found in the upper orbicularis oris muscle (before vs. 30 days, Conclusion: Hyaluronic acid lip filling initially relaxed the orbicularis oris muscle at 30 days. By 60 days, the upper muscle's activity increased, indicating adaptation, while the lower muscle remained less active during cheek inflation, showing distinct functional changes after 60 days.

Indexed as

EMGfacial harmonizationhyaluronic acidlipsorbicularis oris muscle

Identifiers

PMID41480306
PMCPMC12755950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.