ArticleQatar medical journal2025
Evaluation of potentially significant drug-drug interactions among patients receiving psychotropic medications: A real-world retrospective study.
Article in Qatar medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Drug-drug interactions (DDIs) can lead to adverse events or altered drug effectiveness, and polypharmacy increases the likelihood of DDIs. This study aimed to explore the prevalence of clinically significant DDIs among patients with mental health problems who are prescribed psychotropic medications. Methodology: This was a retrospective observational study that included patients who had visited the Outpatient Mental Health Pharmacy at Mental Health Services (MHS) in Qatar for medication dispensing. The study covered all individuals over 2 months, totaling 1586 patients. The list of medications was cross-referenced with Lexicomp Results: Of the 1586 files reviewed, 49% of the patients did not experience any DDIs, while the remaining 51% ( Conclusions: The study provided valuable insight into the prevalence of potential DDIs among patients prescribed psychotropic medications in Qatar. Notably, the analysis highlighted significant interactions, particularly those associated with severe outcomes, like Torsades de Pointes and anticholinergic intoxication. These findings underscore the need for targeted strategies to mitigate adverse effects and enhance patient safety in clinical practice.
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