ReviewSmart molecules : open access2025
Understanding of endo/lysosomal escape of nanomaterials in biomedical application.
Review in Smart molecules : open access, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- DNA/RNA Hybrid Hairpin Gold Nanobeacons Targeting miR-31 Reprogram Invasion in Lung Cancer and Remodel Tumor Histo-ArchitectureACS materials Au · 2026Article
- Nanoparticles for antiviral nucleotide analogs: approaches and analytical challenges.Journal of virology · 2026Review
- Size-Dependent Metabolic Reprogramming in A549 Cells Induced by Mesoporous Silica Nanoparticles: Insights from Subcellular Targeting.Metabolites · 2026Article
- Ultrasmall Cyclodextrin-Based Nanogels as Drug Delivery Systems.ChemistryOpen · 2026Article
- Carrier-Free Nanoassembly Suppresses Phase Separation via Ribosome-Inspired Crowding Control for Enhanced Chemo-Immunotherapy.ACS nano · 2026Article
- A lysosomal escape-enabled endoplasmic reticulum-targeting BODIPY photothermal agent for enhanced tumor ablation.Smart molecules : open access · 2026Article
- Smart Nanoparticles Are Not Smart Enough (Yet): A Cell-Aware View of Cancer Nanomedicine.Cells · 2026Article
- Article
- Small Particles, Big Impact: Inorganic Nanotechnology for Glioblastoma.Molecules (Basel, Switzerland) · 2026Review
- A universal "Divide-and-conquer, precise reconstruction" strategy: Multiscale simulation-guided high-fidelity restoration and controlled release of rose aroma.Current research in food science · 2026Article
- Understanding of endo/lysosomal escape of nanomaterials in biomedical application.Smart molecules : open access · 2025Review
- A photoactivatable tumor-targeting in situ nanovaccine for large-volume tumor therapy.Smart molecules : open access · 2025Article
- Inorganic Silica Nanoparticles Increase Lysosomal Biology and Protease Activity.International journal of molecular sciences · 2025Article
- Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy.Nature communications · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging therapies rely on the efficient and specific delivery of targeted agents into the cytosol, such as DNA, siRNA and proteins. Nanoparticles showed great potentials in safe delivery and transportation of the targeted cargoes; however, the entrapment in endosomes and degradation by specific enzymes in the lysosome hindered the bioavailability, cytosolic delivery and subsequent therapeutic efficacy. In this case, the development of methods for efficient and specific delivery of targeted therapeutic agents focuses on overcoming the major challenge of endo/lysosomal escape, which relies on the development of safe and efficient nano-delivery systems. A deeper mechanistic understanding in the endo/lysosomal escape will guide the development of more efficient nano-delivery systems. In this review, we summarize various mechanisms by which nanoparticles escape from the endo/lysosome, and showcase the recent progress in dissecting the endo/lysosomal approaches based on nano-delivery systems. Emphasis will lie on the properties of nanoparticles that govern the endo/lysosomal escape pathway as well as the latest promising applications in vaccine delivery and genetic engineering field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.