Evidence map›Paper›PMID 41480209›Full record

ArticleWorld journal of gastrointestinal oncology2025

Clinical characteristics of colorectal polyps in patients with non-alcoholic fatty liver disease in high altitude areas.

Chun-Yan Wang, Lin Ma, Ying Zhao, Xiao-Jiang Zhang, Shuang Li, Yong-Gang Liu, Hai-Ming Guo, Jun-Guo Qi, Jian-Quan Wang, Wei-Xin Ye and 2 more

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Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chun-Yan WangDepartment of Gastroenterology, Tianjin Second People's Hospital, Tianjin Institute of Hepatology, Clinical School of the Second People's Hospital, Tianjin Medical University, Tianjin 300110, China.
Lin MaGraduate School, Tianjin Medical University, Tianjin 300070, China.
Ying ZhaoGraduate School, Tianjin Medical University, Tianjin 300070, China.
Xiao-Jiang ZhangGraduate School, Tianjin Medical University, Tianjin 300070, China.
Shuang LiEndoscopy Center, Tianjin Second People's Hospital, Tianjin 300110, China.
Yong-Gang LiuDepartment of Pathology, Tianjin Second People's Hospital, Tianjin 300110, China.
Hai-Ming GuoDiagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People's Hospital, Xining 810003, Qinghai Province, China.
Jun-Guo QiDiagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People's Hospital, Xining 810003, Qinghai Province, China.
Jian-Quan WangDiagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People's Hospital, Xining 810003, Qinghai Province, China.
Wei-Xin YeDiagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People's Hospital, Xining 810003, Qinghai Province, China.
Jian-Zhou LiDiagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People's Hospital, Xining 810003, Qinghai Province, China.
Tao ZhangDiagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People's Hospital, Xining 810003, Qinghai Province, China. zhangtaoqh@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer has high global incidence and mortality rates. Colorectal polyps are relatively common, with adenomatous polyps having a higher risk of malignant transformation. Non-alcoholic fatty liver disease (NAFLD) has been identified as a risk factor for the development of colorectal adenomas. Here, inpatients with NAFLD from the Second People's Hospital of Xining, in Qinghai Province, and the Second People's Hospital of Tianjin were investigated, comparing the biochemical indicators, colonoscopy findings, and pathological results of polyps between patients from low-altitude (Tianjin) and high-altitude (Qinghai Province) areas. Risk factors associated with the occurrence of adenomatous polyps in NAFLD patients from high-altitude areas were also explored.

aimTo investigate the clinical characteristics of colorectal polyps in NAFLD patients from high-altitude areas.

methodsA total of 848 patients with NAFLD were enrolled. Of these, 118 underwent colonoscopy between January 2021 and January 2024 at the Second People's Hospital of Tianjin (low-altitude), while the remaining 730 patients were assessed during the same period at the Second People's Hospital of Xining, Qinghai (high-altitude). All enrolled patients met the diagnostic criteria for NAFLD, and the excised colorectal polyps were analyzed pathologically.

resultsColorectal polyps were found in 585 cases (80.1%) in the Qinghai cohort and 91 patients (77.1%) in the Tianjin group, indicating a slightly higher incidence in the Qinghai group, although the difference was non-significant (

conclusionPatients with NAFLD from high-altitude regions have a higher incidence of colorectal polyps, with a significantly higher incidence of adenomatous polyps compared to other polyp types. Sex, smoking, hypertension, and WBC are risk factors for adenomatous polyps in NAFLD patients in high-altitude regions.

Indexed as

Colorectal polypsEndoscopic manifestationsNon-alcoholic fatty liver diseasePathological resultsQinghai region

Identifiers

PMID41480209
PMCPMC12754325

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