Re-Epithelialization Comparison Between Topical Administration of 1% Feracrylum and Silver Sulfadiazine in the Treatment of Deep Dermal Burns in Wistar Rats.

The gold standard burn dressing silver sulfadiazine (SSD) is widely used, but many disadvantages have been reported. An alternative is 1% feracrylum (1FA), a hemostatic agent that provides antibacterial activity, and wound improvement has been clinically proven. This study aimed to investigate the effect of 1FA in re-epithelization in burn wound management. This experimental study used 27 healthy male Wistar rats. All received inhalation anesthesia, then were prepared for deep burn injury using a metal plate. The animals were treated with either 1FA, SSD, or moist saline gauze (control group). The wound was measured with a two-ruler method on days 0, 5, 10 and 14. On day 14, quantitative and qualitative assessments of re-epithelialization were made. The percentage of wound healing was significantly better in the 1FA group compared to the control and SSD groups (p <0.001 on day 5; p<0.001 on day 10, and p <0.001 on day 14). The histopathology evaluation revealed that the epithelial thickness was significantly greater in the 1FA group compared to the control and SSD groups (p<0.001). The granulation tissue thickness was greater in the SSD group compared to the control and 1FA groups (p<0.001). The neovascularization in the 1FA group was more mature compared to the control and SSD groups (p<0.001). In this animal study, 1FA administration showed improved wound healing and re-epithelialization of the skin after deep dermal burns. These findings may lead to a new therapeutic approach for burn wound healing.