Evidence map›Paper›PMID 41480044›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population.

Kathryn Step, Emily Waldo, Thiago Peixoto Leal, Marla Mendes, Soraya Bardien, Ignacio F Mata

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kathryn StepDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-4054-7030
Emily WaldoGenome Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH, United States.ORCID 0009-0009-1485-3710
Thiago Peixoto LealGenome Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH, United States.ORCID 0000-0002-5829-6452
Marla MendesThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.ORCID 0000-0002-6114-7482
Soraya BardienDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-3508-3438
Ignacio F MataGenome Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH, United States.ORCID 0000-0003-1198-0633

Funding

Additional Sequencing for the Alzheimer Disease Sequencing Project (ADSP) the Follow-Up Study (FUS), The Global Population InitiativeU01AG076482 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Clifton L Dalgard, ANTHONY JOHN GRISWOLD · 2022 to 2026
$26.9M
Modeling the impact of Women's Specific Health Factors in PD outcomes in LatinasR01NS112499 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FERNANDEZ MATA, IGNACIO · 2020 to 2024
$3.3M
The Interplay between Genetics and Aerobic Exercise to Slow Parkinson's disease (GEARS) TrialR01NS132437 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI JAY L. ALBERTS · 2024 to 2026
$1.8M
BLRD VA I01 BX005978NIA NIH HHS U01 AG076482NINDS NIH HHS R01 NS112499NINDS NIH HHS R01 NS132437
6 · The paper itself

Abstract

X chromosome-wide association studies (XWAS) have successfully identified risk loci on the X chromosome associated with Parkinson's disease (PD) susceptibility. However, only three such studies have been completed to date. Here, we present the first XWAS using an African cohort, comprising 690 PD cases and 826 controls. We applied an established XWAS workflow to perform male- and female-stratified analyses, as well as a combined meta-analysis. The male-stratified analysis identified five significant variants, including one lead locus (rs200539602), while the female-stratified analysis revealed 29 significant variants and two lead loci (rs2499550 and rs58045540), where rs2499550 is an upstream variant of the protein-coding gene

Indexed as

GP2Parkinson’s diseaseSouth AfricaX chromosome-wide association study

Identifiers

PMID41480044
PMCPMC12755251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.