Evidence map›Paper›PMID 41480040›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Mapping the prevalence of molecular markers of

Neeva Wernsman Young, Cécile P G Meier-Scherling, Gina Cuomo-Dannenburg, George A Tollefson, Sean V Connelly, Jacob Marglous, Isabela Gerdes Gyuricza, Kelly Carey-Ewend, Ronald Kyong-Shin, Zachary R Popkin-Hall and 13 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Neeva Wernsman YoungCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-0131-7670
Cécile P G Meier-ScherlingCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-7833-5164
Gina Cuomo-DannenburgMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.
George A TollefsonCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-7924-7844
Sean V ConnellyMD-PhD Program, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7330-7340
Jacob MarglousCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-3592-1382
Isabela Gerdes GyuriczaCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7969-1910
Kelly Carey-EwendMD-PhD Program, University of North Carolina, Chapel Hill, NC, USA.
Ronald Kyong-ShinCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0009-0005-6522-4069
Zachary R Popkin-HallInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-8308-5294
Ayalew Jejaw ZelekeDepartment of Medical Parasitology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.
Deus S IshengomaIfikara Health Institute, Ifikara, Tanzania.ORCID 0000-0003-2040-3416
Abebe A FolaDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Alfred SimkinDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Karamoko NiaréDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Jonathan B ParrInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Melissa ConradDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Lucy C OkellMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.
Shazia Ruybal-PesántezMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.ORCID 0000-0002-0495-179X
Oliver J WatsonMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.ORCID 0000-0003-2374-0741
Jonathan J JulianoMD-PhD Program, University of North Carolina, Chapel Hill, NC, USA.
Jeffrey A BaileyCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-6899-8204
Robert VerityMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.ORCID 0000-0002-3902-8567

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY, MOSES Robert KAMYA · 2010 to 2026
$29.3M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Tracking the flow of malaria parasites and drug resistance within the DRC and across its bordersR01AI139520 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAILEY, JEFFREY A. · 2018 to 2023
$3.6M
Epidemiology and determinants of emerging artemisinin-resistant malaria in EthiopiaR01AI177791 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan Boyd Parr · 2023 to 2026
$3.2M
Artemisinin Resistance in Africa: its emergence and evolution in RwandaR01AI156267 · NIAID · BROWN UNIVERSITY · PI BAILEY, JEFFREY A., JULIANO, JONATHAN J · 2021 to 2024
$3.0M
Surveillance to track and characterize antimalarial resistance trends in Ugandan Plasmodium falciparum parasites (STARTUP)R01AI173557 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Melissa D Conrad · 2023 to 2026
$2.9M
Importation and transmission of malaria in Zanzibar: a case study for eliminationR01AI155730 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J, LIN, JESSICA · 2021 to 2024
$2.8M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Data and analysis ecosystem for eukaryotic pathogen targeted sequencingU01AI184646 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENHOUSE, BRYAN R · 2024 to 2025
$1.5M
Predicting the spread of antimalarial drug resistance using deep learning surrogatesR01AI190302 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano, Robert Verity · 2025 to 2026
$1.3M
Investigating the molecular mechanisms of Plasmodium vivax invasion in Duffy-negative hostsF30AI183592 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sean Connelly · 2024 to 2026
$130k
Gates Foundation INV-031273NIAID NIH HHS F30 AI183592NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI139520NIAID NIH HHS R01 AI155730NIAID NIH HHS R01 AI156267NIAID NIH HHS R01 AI173557NIAID NIH HHS R01 AI177791NIAID NIH HHS R01 AI190302NIAID NIH HHS U01 AI184646NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

Background: Methods: We conducted a systematic literature review (PROSPERO-ID CRD42024593923) spanning the years 2014-2025, complementing existing data from WWARN, MalariaGEN Pf7, and the WHO Malaria Threats Map. This integrated dataset, comprising 3,806 distinct molecular epidemiology surveys and 182,071 genotyped samples, was harmonized using a standardized data schema. We applied a spatial-temporal Gaussian process model to estimate the continuous prevalence of WHO Findings: ART-R increases were driven by distinct emergences of Interpretation: The rapid and multicentric expansion of

Indexed as

antimalarial resistanceCRTGaussian processK13kelchmalariaMDR1molecular epidemiologyPlasmodium falciparumspatio-temporal modelling

Identifiers

PMID41480040
PMCPMC12755267

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.