Evidence map›Paper›PMID 41480028›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.

Mengyu Zhang, Michael R Brown, Amy R Bentley, Thomas W Winkler, Raymond Noordam, Pavithra Nagarajan, Bohong Guo, Songmi Lee, Karen Schwander, Wenyi Wang and 235 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

245 authors.

Mengyu ZhangDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-5545-0354
Michael R BrownHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID 0000-0003-0292-5421
Raymond NoordamDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Pavithra NagarajanDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0036-9970
Bohong GuoDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Songmi LeeMcGovern Medical School, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Karen SchwanderDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Wenyi WangDepartment of Human Genetics, Leiden University Medical Center, Leiden, South Holland, the Netherlands.
Kenneth WestermanClinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7619-1868
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Farah AmmousSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Anna D Argoty-PantojaDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Chiara BatiniGenetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK.
Palwende R BouaClinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Ouagadougou, Kadiogo, Burkina Faso.
Heather J CordellPopulation Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Laia Díez-AhijadoUnit of Genomics of Complex Disease, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Catalonia, Spain.
Latchezar DimitrovDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anh N DoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
Jiawen DuDepartment of Biostatistics, University of North Carolina at Chapel Hill, NC.ORCID 0000-0003-3711-8101
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-0933-2410
Ayush GiriDivision of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Franco GiulianiniDivision of Preventive Medicine, Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Valborg GudmundsdottirIcelandic Heart Association, Kopavogur, Iceland.
Xiuqing GuoGenomic Outcomes, Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sarah E HarrisLothian Birth Cohorts, Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4941-5106
Natalie R HasbaniDepartment of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Janina M HeroldDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Keiko HikinoLaboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Fang-Chi HsuDivision of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Minjung KhoGraduate School of Data Science, Seoul National University, South Korea.
Aldi T KrajaUniversity of Mississippi Medical Center, Jackson, MS, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Aline MeirhaegheLille University; Lille University Hospital; INSERM U1167 - RID-AGE; Institut Pasteur de Lille, University of Lille, Inserm, Institut Pasteur de Lille, Lille, France.
Manon MuntanerLille University; Lille University Hospital; INSERM U1167 - RID-AGE; Institut Pasteur de Lille, University of Lille, Inserm, Institut Pasteur de Lille, Lille, France.
Masahiro NakatochiPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.ORCID 0000-0002-1838-4837
Giuseppe Giovanni NardoneDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Teresa NutileInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Alessandro PecoriInstitute for Maternal and Child Health, I.R.C.C.S. "Burlo Garofolo", Trieste, Italy.
Varun S RaoGraduate Program in Life Sciences, University of Maryland, Baltimore, Baltimore, MD, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Mihir M SanghviWilliam Harvey Research Institute, Centre for Pharmacology and Precision Medicine, Queen Mary University of London, London, UK.
Aurora SantinDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Botong ShenNational Institute on Aging, Bethesda, MD, USA.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Fumihiko TakeuchiDepartment of Bioinformatics, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-ku, Tokyo, Japan.ORCID 0000-0003-3185-5661
Ye An TanSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, Singapore.
Jingxian TangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Sébastien ThériaultDepartment of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Quebec, Canada.
Olga TrofimovaDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
Zhe WangThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yujie WangGillings School of Global Public Health, Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Ananda Rajitha WickremasingheFaculty of Medicine, University of Kelaniya, Kelaniya, Ragama, Sri Lanka.
Chenglong YuSchool of Public Health and Preventive Medicine, Monash University, Victoria 3004 Australia.
Wanying ZhuGenetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Md Abu Yusuf AnsariDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Pramod AnuguJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Bernhard BanasDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
R Graham BarrGeneral Medicine, Medicine, Columbia University Medical Center, New York, NY, USA.
Til B BasnetTennessee Valley Healthcare System, Nashville VA Medical Center, Nashville, TN, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Max BreyerDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Luke BryantDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Brian CadeDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1424-0673
Silvia CamardaDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Pasqualina CennamoInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
William CheckleyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-1106-8812
Miao-Li CheeSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Singapore.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USA.
Kayesha ColeyGenetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK.
Stacey D CollinsSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Martin H de BorstNephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Lisa de Las FuentesCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
Ian J DearyLothian Birth Cohorts, Psychology, The University of Edinburgh, Edinburgh, UK.
Charles T DupontDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Christian EnzingerDivision of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria.
Tariq FaquihDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-8026-2251
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6969-6478
Lilian Fernandes SilvaInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Victoria GauthierLille University; Lille University Hospital; INSERM U1167 - RID-AGE; Institut Pasteur de Lille, University of Lille, Inserm, Institut Pasteur de Lille, Lille, France.
Adam D GepnerCardiovascular Medicine, Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mathias GorskiDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Mariaelisa GraffGillings School of Global Public Health, Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Charles C GuCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-8527-8145
Jiang HeDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Bertha HidalgoEpidemiology, UAB School of Public Health, Birmingham, Alabama, USA.
Heather M HighlandGillings School of Global Public Health, Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
James E HixsonDepartment of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Michelle M HoodDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Steven C HuntEpidemiology, Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Marguerite Ryan IrvinEpidemiology, UAB School of Public Health, Birmingham, Alabama, USA.
Masato IsonoDepartment of Gene Diagnostics and Therapeutics, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-ku, Tokyo, Japan.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Carrie A Karvonen-GutierrezDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Anuradhani KasturiratneFaculty of Medicine, University of Kelaniya, Kelaniya, Ragama, Sri Lanka.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita-shi, Osaka, Japan.
Joel D KaufmanEpidemiology, University of Washington Seattle, Seattle, WA, USA.ORCID 0000-0003-4174-9037
Heikki A KoistinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Bernhard K KrämerFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
Lenore J LaunerIntramural Research Program, Laboratory of Epidemiology and Population Sciences, Intramural Research Program, Laboratory of Epidemiology and Population Sciences.
Hampton LeonardNIH Center for Alzheimer's and Related Dementias, Bethesda, MD, USA.
Daniel LevyFramingham Heart Study, Framingham, MA, USA.ORCID 0000-0003-1843-8724
Lifelines Cohort Study
Jianjun LiuGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, Singapore.
Pedro Marques-VidalInternal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Angel Martinez-PerezUnit of Genomics of Complex Disease, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Catalonia, Spain.ORCID 0000-0002-5934-1454
Koichi MatsudaInstitute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Victoria 3004 Australia.
Yuri MilaneschiPsychiatry, Amsterdam, the Netherlands.
J Jaime MirandaCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0002-4738-5468
John L MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Michael NallsNIH Center for Alzheimer's and Related Dementias, Bethesda, MD, USA.
Maggie Cy NgVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.
Anniina OravilahtiInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Amit PatkiBiostatistics, UAB School of Public Health, Birmingham, Alabama, USA.
Lauren E PettyGenetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Giulia PianigianiDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7892-193X
Olli T RaitakariCentre for Population Health Research, Turku University Hospital, Turku, Finland.
Michele RamsaySydney Brenner Institute for Molecular Bioscience (SBIMB), University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
Ken M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Paul M RidkerDivision of Preventive Medicine, Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Lorenz RischInstitute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
Martin RischDr. Risch Medical Laboratory, Vaduz, Liechtenstein.
Daniela RuggieroInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
Edward A Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA.
Tom C RussLothian Birth Cohorts, Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9797-2188
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Singapore.
Nataraja Sarma VaitinadinDivision of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Laura J ScottCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Surina SinghSydney Brenner Institute for Molecular Bioscience (SBIMB), University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
Colleen M SitlaniCardiovascular Health Research Unit, General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Roelof A J SmitThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3575-5468
Quan SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, NC.ORCID 0000-0001-8324-2803
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, Singapore.
Kent D TaylorGenomic Outcomes, Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Paola TesolinDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Singapore.
Biobank Japan Project
Chikowore TinasheChanning Division of Network Medicine, Department of Medicine, Brigham Hospital, Harvard University, Boston, Massachusetts, USA.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, Singapore.
Julien VaucherInternal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Chaolong WangSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei, China.ORCID 0000-0003-3945-1012
Otis D WilsonTennessee Valley Healthcare System, Nashville VA Medical Center, Nashville, TN, USA.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Singapore.
Jianzhao XuDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Jie YaoGenomic Outcomes, Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Mitsuhiro YokotaKurume University School of Medicine, Kurume, Fukuoka, Japan.
Kristin L YoungGillings School of Global Public Health, Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Martina E ZimmermannDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Philippe AmouyelLille University; Lille University Hospital; INSERM U1167 - RID-AGE; Institut Pasteur de Lille, University of Lille, Inserm, Institut Pasteur de Lille, Lille, France.
Jennifer E BelowGenetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sven BergmannDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Antonio Bernabe-OrtizCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0002-6834-1376
Laura BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jean-Tristan BrandenburgSydney Brenner Institute for Molecular Bioscience (SBIMB), University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0003-0197-2648
Daniel I ChasmanDivision of Preventive Medicine, Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Singapore.
Marina CiulloInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
Maria Pina ConcasInstitute for Maternal and Child Health, I.R.C.C.S. "Burlo Garofolo", Trieste, Italy.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Simon R CoxLothian Birth Cohorts, Psychology, The University of Edinburgh, Edinburgh, UK.
Luc DauchetLille University; Lille University Hospital; INSERM U1167 - RID-AGE; Institut Pasteur de Lille, University of Lille, Inserm, Institut Pasteur de Lille, Lille, France.
Hithanadura Janaka de SilvaFaculty of Medicine, University of Kelaniya, Kelaniya, Ragama, Sri Lanka.
Marcus DörrCardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ervin R FoxJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC.
Barry I FreedmanSection on Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Giorgia GirottoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Sioban D HarlowDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Iris M Heidnational Institute of Global Health and Medicine, University of Regensburg, Regensburg, Germany.
Adriana M HungTennessee Valley Healthcare System, Nashville VA Medical Center, Nashville, TN, USA.
Sahoko IchiharaDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Cashell E JaquishDivision of Cardiovascular Science, Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Catherine JohnGenetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK.
Jost B JonasPrivatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany, Germany.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-ku, Tokyo, Japan.
Bernard D KeavneyCardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Tanika N KellyDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Victoria 3004 Australia.ORCID 0000-0002-0902-6798
Timo LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Seunggeun LeeGraduate School of Data Science, Seoul National University, South Korea.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID 0000-0002-2555-4427
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-0703-0742
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kari E NorthGillings School of Global Public Health, Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brenda PenninxPsychiatry, Amsterdam, the Netherlands.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Bruce M PsatyCardiovascular Health Research Unit, General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USA.ORCID 0000-0001-5759-053X
Jerome I RotterGenomic Outcomes, Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Maria Sabater-LlealUnit of Genomics of Complex Disease, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Catalonia, Spain.ORCID 0000-0002-0128-379X
Helena SchmidtDivision of Genetic Epidemiology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, Singapore.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Beatrice SpedicatiDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Klaus J StarkDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Lynne E WagenknechtDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Patricia B MunroeClinical Pharmacology and Precision Medicine, Queen Mary University of London, London, UK.ORCID 0000-0002-4176-2947
Yan V SunRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-2838-1824
James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Alisa K ManningClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-0247-902X
Myriam FornageMcGovern Medical School, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-0677-8158
Hugues AschardDepartment of Computational Biology, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-7554-6783
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-1486-7495
Paul S de VriesHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Gao WangCenter for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
Dabeeru C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Han ChenHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-9510-4923

Funding

A Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8M
A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3M
Methods and Software for Large-Scale Gene-Environment Interaction StudiesR01HL145025 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHEN, HAN, MANNING, ALISA KNODLE · 2019 to 2023
$4.0M
Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
CSRD VA I01 CX001897NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL145025NHLBI NIH HHS R01 HL156991NHLBI NIH HHS R01 HL172803
6 · The paper itself

Abstract

Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies in five ancestry groups, analyzing systolic BP, diastolic BP, and pulse pressure while considering interactions between genetic variants and three smoking exposures: smoking status, cigarettes per day, and pack years. These analyses identified twelve novel loci for BP at genome-wide significance (

Indexed as

blood pressurefine mappinggene by smoking interactionGWASjoint test

Identifiers

PMID41480028
PMCPMC12754705

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