ArticleWorld journal of cardiology2025
Predictors of life-threatening events in adult patients with left ventricular noncompaction.
Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLeft ventricular noncompaction (LVNC) is a genetic cardiomyopathy. It is characterized by intensely developed trabeculae in the ventricles with deep intertrabecular lacunae. LVNC manifests as arrhythmias and heart failure with a predisposition for thrombus formation.
aimTo study predictors of arrhythmic, thromboembolic events and adverse outcomes (death/transplantation) in adult patients with LVNC.
methodsAdult patients with LVNC were included (
resultsLVNC manifestations included non-sustained VT, thrombosis/embolism, sustained VT, and sudden cardiac death. Non-sustained VT was associated with the New York Heart Association (NYHA) chronic heart failure (CHF) class, poor R-wave progression, superimposed myocarditis, and higher mortality. Thrombosis/embolism was associated with NYHA CHF class ≥ 3, right ventricular end-diastolic diameter ≥ 3 cm, right atrium volume ≥ 67 mL, left ventricle end-diastolic diameter ≥ 6.3 cm, and velocity time integral ≤ 11.2 cm. Sustained VT was associated with premature ventricular contractions (PVCs), low QRS voltage, and atrioventricular block. PVCs > 500/day were predictive of defibrillator intervention. Fatal outcomes were associated with E wave/A wave ratio > 1.9, left ventricle ejection fraction < 35%, NYHA CHF class ≥ 3, VT, and myocarditis.
conclusionFrequent PVCs, non-sustained VT, low QRS voltage, and signs of systolic dysfunction on echocardiogram are predictors of life-threatening events in patients with LVNC.
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