Evidence map›Paper›PMID 41479945›Full record

ArticleJournal of medical devices2026

Verification and Validation of an Autotuning Proportional-Integral-Derivative Controller for Spatially Confined Magnetic Particle Hyperthermia.

Shreeniket Pawar, Hayden Carlton, Yash Sharad Lad, Lyndsey Werhane, Ma'Moun Abu-Ayyad, Preethi Korangath, Robert Ivkov, Anilchandra Attaluri

Abstract read
In one paragraph

Article in Journal of medical devices, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
  2. Design, verification and validation of a spatially confined magnetic nanoparticle thermal therapy device for conformal thermal dose contouring.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
  3. Feasibility of thermal dose painting during magnetic nanoparticle thermal therapy: a computational analysis.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shreeniket PawarDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057.ORCID https://orcid.org/0009-0005-2574-1176
Hayden CarltonDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231.ORCID https://orcid.org/0000-0002-2249-3067
Yash Sharad LadDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057.ORCID https://orcid.org/0009-0001-3084-6862
Lyndsey WerhaneDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231.ORCID https://orcid.org/0009-0005-0811-8227
Ma'Moun Abu-AyyadDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057.ORCID https://orcid.org/0000-0003-0558-9312
Preethi KorangathDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231.ORCID https://orcid.org/0000-0002-6623-493X
Robert IvkovDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218.ORCID https://orcid.org/0000-0002-2930-5276
Anilchandra AttaluriDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057.ORCID https://orcid.org/0000-0003-0283-1927

Funding

Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
NCI NIH HHS R01 CA247290NCI NIH HHS R01 CA257557
6 · The paper itself

Abstract

We have previously verified the capabilities of a prototype magnetic nanoparticle (MNP) heater (called HYPER) that can perform spatially confined heating; however, the design lacked temperature control capabilities. In this work, we designed, verified, and validated a relay-based autotuning proportional-integral-derivative (PID) controller to be used with the HYPER during in vivo experiments. The PID controller is an autotuning, relay-based controller with several design constraints: The controller must: (1) maintain tumor temperature within hyperthermic range of 41-46 °C; (2) rise time ≤ 5 min; (3) steady-state temperature must be within ±0.5 °C of the setpoint; (4) standard deviation of steady-state temperature within ±0.5 °C; and (5) temperature overshoot within 5%. The relay-based autotuning PID controller was designed in LabVIEW

Indexed as

magnetic nanoparticles (MNPs)proportional–integral–derivative (PID) controllerrelay feedbackspatially confined magnetic particle hyperthermia (SC-MPH)verification and validation

Identifiers

PMID41479945
PMCPMC12755161

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.