Evidence map›Paper›PMID 41479895›Full record

ArticleFrontiers in immunology2025

Bioinformatic and experimental identification and characterization of

Soumyadeep Chakraborty, Joshua Heuler, Shaohui Wang, Junling Qin, Adrit Roy, Lubem Nathanel Agbendeh, Anastasia Tomatsidou, Hyeun Bum Kim, Xingmin Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Soumyadeep ChakrabortyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Joshua HeulerDepartment of Biological Sciences, Fralin Life Sciences Institute, and Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, VA,, United States.
Shaohui WangDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Junling QinDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Adrit RoyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Lubem Nathanel AgbendehDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Anastasia TomatsidouDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Hyeun Bum KimDepartment of Animal Biotechnology, Dankook University, Chenonan, Republic of Korea.
Xingmin SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

Funding

Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Clostridioides difficile Zinc-binding PBPs as anti-sporulation targetsR01AI185760 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CHEN, YU, SUN, XINGMIN · 2025 to 2025
$2.9M
Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
Development of probiotic-based and Clostridioides difficile-targeted therapeuticsR21AI183094 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN, ZHANG, YONGRONG · 2024 to 2025
$431k
NIAID NIH HHS R01 AI132711NIAID NIH HHS R01 AI149852NIAID NIH HHS R01 AI185760NIAID NIH HHS R21 AI183094
6 · The paper itself

Abstract

Introduction: Treatment options for Methods: Lipoprotein sequences were aligned, analyzed, and evaluated for their immune properties. The antigenic characteristics of both LP1 and LP2 were assessed in silico and in a mouse model of immunization and CDI. Results: Multiple sequence alignments showed that the lipoprotein sequences were highly conserved among various ribotypes. Discussion: These results indicate that both lipoproteins play a significant role in

Indexed as

Bacterial ProteinsBacterial VaccinesClostridioides difficileClostridium InfectionsLipoproteinsAnimalsAntibodies, BacterialAntigens, BacterialComputational BiologyDisease Models, AnimalFemaleHumansMiceAntibodies, BacterialAntigens, BacterialBacterial ProteinsBacterial VaccinesLipoproteinsadhesionClostridioides difficilecolonizationepitope analysislipoproteinmouse modelvaccine

Identifiers

PMID41479895
PMCPMC12753941

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.