Trial reportFrontiers in immunology2025
Efficacy and safety of the neoadjuvant chemoimmunotherapy with pembrolizumab plus docetaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and neck.
Trial report in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of immunotherapy in head and neck tumors: a systematic review and meta-analysis of clinical outcomes and survival benefits.Frontiers in oncology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) is the most common type of tumor originating from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. There is an urgent need to enhance therapeutic efficacy and ensure the function preservation of HNSCC treatment. This study aimed to evaluate the efficacy and safety of neoadjuvant chemoimmunotherapy with pembrolizumab plus docetaxel and cisplatin in patients with resectable locally advanced HNSCC. Methods: This was a prospective single-center, single-arm, open-label, phase II study involving patients with locally advanced HNSCC who were treated with pembrolizumab (200 mg) plus docetaxel (50 mg/m Results: Overall, 52 patients with HNSCC were enrolled (45 males/7 females), with a median age of 61 years. The ORR rate was 87.8% (95% confidence interval [CI]: 75.2-95.4). Of the 27 patients who underwent resection, 12 (44.4%, 95% CI: 25.5-64.7) achieved a pCR and 15 (55.6%, 95% CI: 35.3-74.5) achieved an MPR. For the overall population, the PFS rates were 89.8% (95% CI: 77.2-95.6), 87.5% (95% CI: 74.2-94.2), and 72.7% (95% CI: 50.6-86.1), and the OS rates were 95.9% (95% CI: 84.7-99.0), 93.6% (95% CI: 81.5-97.9) and 84.9% (65.0-93.9), at 6 months, 12-months and 18 months, respectively. The most common adverse events were nausea/vomiting (12.2%), fatigue (10.2%), rash (8.2%), neurotoxicity (8.2%) and aminotransferases elevation (8.2%). Grades 3 and 4 adverse events occurred in 12 (24.5%) and 2 (4.1%) patients, respectively. Conclusions: Pembrolizumab plus docetaxel and cisplatin reveals encouraging survival benefit with a manageable safety profile in patients with HNSCC.
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