ArticleWorld journal of gastrointestinal pathophysiology2025
Gender, racial, and stage-specific trends in esophageal cancer: Insights from longitudinal population data.
Article in World journal of gastrointestinal pathophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Immune exhaustion in esophageal cancer: interferon pathway dysregulation and neoadjuvant therapy response.Frontiers in cell and developmental biology · 2026Review
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5 authors.
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Abstract
backgroundEsophageal cancer is a significant global health concern, characterized by high mortality rates and diverse histological types, primarily adenocarcinoma and squamous cell carcinoma.
aimTo analyze trends in esophageal cancer using Surveillance, Epidemiology, and End Results (SEER) data, focusing on patient characteristics, stage at diagnosis, treatment modalities, and survival outcomes, to provide insights that may guide clinical practice and public health initiatives.
methodsAge-adjusted incidence and mortality rates for esophageal cancer, 2004-2021, were obtained from SEER rate sessions using SEER*Stat version 8.4.4. Average percent changes (APC) over time in age-adjusted incidence and mortality rates relative to gender, race/ethnicity, and stage at diagnosis were assessed using Joinpoint's log-linear regression. Finally, Poisson regression was used to ascertain incidence and mortality rate ratios to ascertain associations between age, gender, race/ethnicity, and staging with incidence and mortality rates. All analyses were further stratified by gender to assess interactions between gender and the other demographic and clinical characteristics.
resultsOverall, the data reveals significant trends in both the incidence and mortality rates of esophageal cancer, with notable variations across gender, race, and stage at diagnosis. Age-adjusted incidence and mortality rates were higher in males compared to females (incidence: 4.1 per 100000
conclusionThe analysis reveals clear disparities in both the incidence and mortality of esophageal cancer, with males, particularly NH Whites, experiencing significantly higher rates than females. Despite a general decline in incidence rates over time, the upward trend in mortality for certain subgroups warrants further investigation into potential contributing factors such as healthcare access, treatment efficacy, and underlying socio-economic disparities.
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