Evidence map›Paper›PMID 41479854›Full record

ArticleInternational journal of endocrinology2025

Efficacy of Compound Betamethasone Periocular Injection Combined With Oral Mycophenolate Mofetil in Active Thyroid-Associated Ophthalmopathy: A Pilot Study.

Chunchun Xiao, Yiwei Liu, Wan Zhou, Yan Xing, Shandong Ye, Bin Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunchun XiaoDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China, ustc.edu.cn.
Yiwei LiuWest China Hospital, Sichuan University, Chengdu, China, scu.edu.cn.
Wan ZhouDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China, ustc.edu.cn.
Yan XingDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China, ustc.edu.cn.
Shandong YeDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China, ustc.edu.cn.ORCID https://orcid.org/0000-0001-5512-9846
Bin HuangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China, ustc.edu.cn.ORCID https://orcid.org/0000-0002-8878-828X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the efficacy of combined therapy of compound betamethasone periocular injection and oral mycophenolate mofetil (MMF) in treating active thyroid-associated ophthalmopathy (TAO). Methods: A retrospective study was conducted on 17 patients with active TAO treated with compound betamethasone periocular injection combined with oral MMF from February 2022 to August 2023, involving a total of 31 eyes. Results: In one eye, the Clinical Activity Score (CAS) decreased by less than two points, while in the remaining eyes, the CAS decreased by two points or more. Patients exhibited decreased proptosis, a reduction in average extraocular muscle thickness, and improvement in diplopia in six cases. Subgroup analysis indicated that this regimen showed no significant difference in efficacy for patients treated with radioactive iodine therapy or oral methimazole medication at baseline. Conclusion: Combined therapy of compound betamethasone periocular injection and oral MMF is an effective approach for treating active TAO.

Indexed as

compound betamethasonemycophenolate mofetilperiocular injectionthyroid-associated ophthalmopathy

Identifiers

PMID41479854
PMCPMC12755051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.