Evidence map›Paper›PMID 41479806›Full record

ArticleFrontiers in neuroscience2025

Regional abnormalities in the hippocampus and verbal memory impairment in craniofacial dystonia.

Gang Liu, Huiming Liu, Linchang Zhong, Yuhan Luo, Zhengkun Yang, Jiana Zhang, Xiuye He, Zilin Ou, Weixi Zhang, Kangqiang Peng and 3 more

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Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gang Liu *Department of Neurology, Huidong People's Hospital, Huizhou, China.
Huiming Liu *State Key Laboratory of Oncology in Southern China, Department of Medical Imaging, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Linchang Zhong *State Key Laboratory of Oncology in Southern China, Department of Medical Imaging, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yuhan LuoGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Zhengkun YangGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Jiana ZhangGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Xiuye HeGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Zilin OuGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Weixi ZhangGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Kangqiang PengState Key Laboratory of Oncology in Southern China, Department of Medical Imaging, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jinping XuInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Zhicong YanGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.
Yue ZhangGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with craniofacial dystonia (CFD) often present with verbal memory deficits, but their neuroanatomical basis is not yet clear. This study aims to determine whether verbal memory deficits in CFD are associated with structural atrophy of specific hippocampal subfields, and to isolate dystonia-specific pathological changes through comparison with patients with hemifacial spasm (HFS). Methods: We recruited 50 patients with CFD, 48 patients with HFS, and 50 healthy controls (HCs). Verbal memory and global cognitive function were assessed using the Rey Auditory Verbal Learning Test (RAVLT) and the Mini-Mental State Examination (MMSE), respectively. Volumes of hippocampal subfields were quantified from high-resolution T1-weighted magnetic resonance imaging (MRI) using FreeSurfer. Group comparisons were performed after controlling for relevant covariates. Results: While global cognition (MMSE) scores did not differ significantly among groups, patients with CFD demonstrated significant verbal memory deficits. Compared with HCs, they performed worse across immediate, short-, and long-delay recall trials, with medium-to-large effect sizes (all Conclusion: Our findings reveal a structure-function dissociation in CFD. We propose its verbal memory deficits, despite hippocampal atrophy, may stem from broader network dysfunction or microstructural pathology not seen on conventional MRI. This challenges models assuming a direct link between macrostructural atrophy and cognitive symptoms.

Indexed as

craniofacial dystoniaFreeSurferhippocampal subfieldsstructural magnetic resonance imagingverbal memory

Identifiers

PMID41479806
PMCPMC12753948

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