ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2025
A Lytic Bacteriophage as a Potential Biocontrol Agent Against Avian Enterotoxigenic
Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Lytic Bacteriophage as a Potential Biocontrol Agent Against Avian EnterotoxigenicThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Diarrheal diseases remain a major public health concern, causing over two million deaths annually in developing countries. Diarrheagenic Methods: ETEC strains were isolated from poultry with colibacillosis and confirmed by LT and ST toxin genes. Their antibiotic resistance and biofilm formation were evaluated. Bacteriophages were isolated from wastewater, and their host range, morphology, growth characteristics, lytic activity, and stability under different temperatures and pH were assessed. Result: The isolated ETEC strain exhibited a multidrug-resistant phenotype and strong biofilm formation. The bacteriophage was highly specific for this strain, showing no lysis of other bacteria, and was classified as belonging to the Autographiviridae family by TEM analysis. One-step growth experiments revealed a latent period of 0-10 min and a burst size of 93 PFU/cell. Lytic activity was effective at MOIs of 10 and 100, and the phage remained stable under typical environmental and physiological conditions, suggesting its potential applicability in poultry. Conclusion: The isolated phage demonstrates high specificity, lytic activity, and stability, indicating its potential as an alternative or adjunct to antibiotics for controlling MDR ETEC in poultry. Further studies are warranted to evaluate its safety and efficacy under in vivo conditions.
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