ArticleWorld journal of gastrointestinal surgery2025
Analysis of antinuclear antibody pattern distribution and correlation in patients with colorectal cancer.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPatients with tumors often develop multiple autoantibodies against tumor-associated antigens. Among these, antinuclear antibodies (ANAs) constitute a clinically important group distributed across the nucleus, cytoplasm, and cytoskeleton. Emerging evidence suggests that ANAs are closely associated with the development and progression of various malignancies, including colorectal cancer (CRC).
aimTo detect ANA fluorescence patterns in CRC using indirect immunofluorescence (IIF) and investigate their correlation with the disease.
methodsWe collected serum samples from patients and healthy controls visiting The Affiliated Panyu Central Hospital of Guangzhou Medical University between May 2023 and March 2024 for analysis. The study included 38 patients with newly diagnosed CRC, 43 patients with colorectal polyps (CRP), and 29 healthy controls. Serum ANA expression was assessed by IIF, and fluorescence patterns were recorded for each group. Differences in ANA titers were compared among each group to analyze the differences in serum ANA-positive expression, which were further analyzed to explore the correlation between ANA expression and CRC screening.
resultsANA positivity rates were 50.00% in the CRC group, 46.51% in the colorectal polyp group, and 6.90% in the healthy control group, with significantly higher rates in the two patient groups compared to the control group (
conclusionANAs are associated with both CRP and CRC and may be useful in early CRC screening. Medium-to-high ANA titers, in particular, should prompt further evaluation for possible CRC correlation. Multiple ANA fluorescence patterns can be detected across all groups, with patients with CRP and CRC showing greater pattern diversity than healthy controls.
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