ArticleWorld journal of gastrointestinal surgery2025
Intra-abdominal pressure and procalcitonin for prognosis in patients with severe acute pancreatitis: An etiology-based analysis.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEarly risk stratification in severe acute pancreatitis (SAP) remains challenging with traditional scoring systems overlooking etiological heterogeneity, particularly in hypertriglyceridemic acute pancreatitis (HTG-AP).
aimTo develop and evaluate a machine learning (ML) model combining intra-abdominal pressure (IAP) and procalcitonin (PCT) for SAP prognosis and evaluate its clinical impact across different etiologies.
methodsWe retrospectively analyzed 245 patients with pancreatitis (98 patients with SAP). An ML model using 24-h peak IAP and PCT levels was used to predict 28-day mortality. Propensity score matching was used to compare IAP-PCT-guided management with conventional management.
resultsThe ML-IAP-PCT model outperformed the Acute Physiology and Chronic Health Evaluation II score (area under the curve: 0.853
conclusionML-optimized IAP-PCT monitoring provides superior prognostic accuracy and guides management associated with improved outcomes, especially in patients with HTG-AP. Prospective validation is needed to establish causality for this etiology-stratified approach.
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