ArticleFrontiers in nutrition2025
CALLY index predicts survival and surgical outcomes in colorectal cancer.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of the CALLY index for functional outcomes in acute ischemic stroke: a systematic review and exploratory quantitative synthesis.Frontiers in neurology · 2026Pooled it
- Deciphering the potential of the C-reactive protein-albumin-lymphocyte index as a prognostic biomarker in malignancy: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Predictors of Metastatic Lymph Node Burden in Colorectal Cancer: A Negative Binomial Regression Analysis.Life (Basel, Switzerland) · 2026Article
- Association between microinflammatory state and cardiac valvular calcification in patients undergoing maintenance hemodialysis: a single-centre observational study.BMC nephrology · 2026Observational
- The association between CALLY index and obesity in adolescents: a comparative analysis with traditional inflammatory markers.Eating and weight disorders : EWD · 2026Article
- Baseline CALLY index is associated with all-cause mortality in HBV-ACLF patients receiving ALSS therapy.Frontiers in medicine · 2026Article
- Multidimensional impact of venous thromboembolism on survival outcomes in ovarian cancer patients: deconstructing competing risks between thrombosis-related and tumor-related mortality.American journal of cancer research · 2026Article
- Which immunonutritional marker best predicts disease-free survival in non-metastatic colorectal Cancer? The CALLY index and CAR emerge as independent predictors from a seven-marker comparison.Frontiers in nutrition · 2026Article
- Achieving ≥70% of energy requirements during early enteral nutrition and short-term inflammatory-metabolic profiles in critically ill patients with sepsis: a prospective cohort study.Frontiers in nutrition · 2026Article
- A clinical study of the CALLY index and HALP score for evaluating response to FOLFOX in colorectal cancer with lung metastases.American journal of translational research · 2026Article
- Association of Pre-treatment CALLY Index With Pathological Response to Neoadjuvant Chemotherapy in Rectal Cancer.In vivo (Athens, Greece)Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The prognostic evaluation of colorectal cancer (CRC) traditionally relies on TNM staging, which fails to incorporate host-related factors such as systemic inflammation, nutrition, and immunity. The C-reactive protein-albumin-lymphocyte (CALLY) index has recently been proposed as a novel biomarker integrating these domains. Methods: We retrospectively analyzed 957 patients with CRC undergoing curative resection (2010-2020). The CALLY index was calculated from preoperative laboratory data. Patients were stratified into high- and low-CALLY groups using ROC-derived cutoffs. Associations with postoperative complications, overall survival (OS), and disease-free survival (DFS) were assessed and compared with other indices (mGPS, PNI, NLR, PLR, SII, CAR). Results: Low CALLY was significantly associated with higher complication rates (23.0% vs. 14.9%, Conclusion: The preoperative CALLY index is a simple, cost-effective, and reliable prognostic biomarker for CRC, predicting both surgical outcomes and long-term survival. Incorporation of CALLY into risk stratification may complement TNM staging, optimize perioperative management, and inform individualized treatment strategies. Further validation in multicenter, prospective cohorts is required to confirm the generalizability of these findings.
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