Evidence map›Paper›PMID 41479669›Full record

ArticleFrontiers in nutrition2025

Impact of sarcopenia on functional and cognitive recovery in Caucasian post-stroke patients following rehabilitation.

Alessandro Guerrini, Mariacristina Siotto, Alessio Fasano, Carola Cocco, Marco Germanotta, Valeria Cipollini, Laura Cortellini, Arianna Pavan, Stefania Lattanzi, Sabina Insalaco and 4 more

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alessandro Guerrini *IRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Mariacristina Siotto *IRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Alessio FasanoIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Carola CoccoIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Marco GermanottaIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Valeria CipolliniIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Laura CortelliniIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Arianna PavanIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Stefania LattanziIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Sabina InsalacoIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Erika AntonacciIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Elisabetta RucoIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Yeganeh Manon KhazraiDepartment of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Rome, Italy.
Irene Giovanna AprileIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & aims: Sarcopenia, a progressive and generalized skeletal muscle disorder, significantly hinders post-stroke recovery. Existing research has focused exclusively on Asian populations, leaving effects in Caucasian cohorts largely unexplored. This study aims to evaluate the impact of sarcopenia, as defined by the European Working Group on Sarcopenia in Older People (EWGSOP2) criteria, on functional and cognitive recovery in subacute post-stroke patients undergoing a rehabilitation program. Methods: Eighty seven subacute post-stroke patients (71 [61-78] years; 42 women) were evaluated at admission (T0) and after 6 weeks of rehabilitation (T1). At T0, demographic, clinical, and nutritional data were collected, and sarcopenia was diagnosed. Functional and cognitive outcomes-including the modified Barthel Index (mBI), Fugl-Meyer Assessment for Upper Extremity (FMA-UE), Motricity Index for upper and lower limbs (MI-UE, MI-LE), Functional Ambulation Category (FAC), and Montreal Cognitive Assessment (MoCA)-were evaluated at both T0 and T1. Functional and cognitive recovery (ΔmBI, ΔFMA-UE, ΔMI-UE, ΔMI-LE, and ΔMoCA) were also assessed. Intra-group (T0 vs. T1) and inter-group comparisons (sarcopenic vs. nonsarcopenic patients) were then evaluated, and a Propensity Score Matching (PSM) analysis was used to adjust for baseline confounding factors. Results: Sarcopenic patients ( Conclusion: Our findings emphasize that sarcopenia negatively affects post-stroke recovery of independence and ambulation, highlighting the importance of early identification and targeted interventions in rehabilitation.

Indexed as

body compositioncognitive recoveryEWGSOP2functional recoverysarcopeniastroke

Identifiers

PMID41479669
PMCPMC12753416

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.