Trial reportFrontiers in nutrition2025
Targeting gut microbiota with short-chain fructo-oligosaccharides prebiotic fibers to support metabolic health in overweight prediabetic adults: a randomized, double-blinded, placebo-controlled study.
Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04767672 (Randomized, Double-Blinded, Placebo-Controlled Study to Assess the Effects of Short-Chain Fructo-Oligosaccharides on Long-Term Glucose Homeostasis in Untreated Prediabetic Subjects), which is not on this map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Double-Blinded, Placebo-Controlled Study to Assess the Effects of Short-Chain Fructo-Oligosaccharides on Long-Term Glucose Homeostasis in Untreated Prediabetic Subjects
Who cites it
6 citing papers in PubMed.
- Trial
- Review
- Short-Chain Inulin and Inulin Neoseries Oligosaccharides from Red Onions Enrich Beneficial Gut Taxa and Attenuate Obesity-Related Outcomes in a Rat Model.Foods (Basel, Switzerland) · 2026Article
- Effect of Chitooligosaccharides-Combination Fortified Noodles Intervention on Visceral Adiposity and Serum Metabolites in a High-Risk Occupational Cohort of Young Seafarers.Food science & nutrition · 2026Article
- Study on Formation of Phosvitin-Fructooligosaccharide Complex and Stability Improvement Mechanisms.Biomolecules · 2026Article
- Short-chain fructo-oligosaccharides modulate gut microbiota composition and metabolism: dose-response assessment in anGut microbes reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives: The global rise in metabolic disorders such as obesity and type 2 diabetes is largely driven by dietary changes and sedentary lifestyles. Prebiotic dietary fibers may help mitigate this trend by modulating gut microbiota. This study aimed to evaluate the effects of short-chain fructo-oligosaccharides (scFOS) on glucose homeostasis, body composition and gut microbiota in overweight individuals with prediabetes. Methods: In this randomized, double-blind, placebo-controlled, parallel arms trial, participants with fasting glycemia between 1 and 1.25 g/L and BMI between 23 and 35 kg/m Results: Participants ( Conclusion: Twelve-week scFOS supplementation in overweight prediabetic adults led to beneficial changes in gut microbiota composition and fermentative activity, along with modest improvements in body composition. Although no significant improvements in glucose homeostasis were observed, this may reflect the moderately impaired metabolic status of participants and interindividual variability in response to prebiotics. Findings nonetheless suggest that scFOS may support gut and metabolic health and contribute to strategies for preventing or delaying metabolic disorders. Clinical trial registration: ClinicalTrials.gov, identifier NCT04767672.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.