Evidence map›Paper›PMID 41479646›Full record

ArticleWorld journal of gastroenterology2025

Ethnic genomic differences in esophageal squamous cell carcinoma: Whole-exome sequencing of Han and Kazakh populations in China.

Meng-Xia Wei, Ling-Ling Lei, Rui-Hua Xu, Yong-Xuan Liu, Ran Wang, Wen-Li Han, Zong-Min Fan, Fan-Kai Xiao, Ilyar Sheyhidin, Lei Ma and 11 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Meng-Xia WeiHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Ling-Ling LeiHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Rui-Hua XuHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Yong-Xuan LiuHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Ran WangHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Wen-Li HanHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Zong-Min FanHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Fan-Kai XiaoHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Ilyar SheyhidinDepartment of Thoracic Surgery and Medical Research Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
Lei MaTumor Laboratory, The First People's Hospital of Nanyang, Nanyang 473000, Henan Province, China.
Jian-Wei KuDepartment of Gastroenterology, The Second Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan Province, China.
Ming-Zhu YinClinical Research Center, Clinical Pathology Center, Cancer Early Detection and Treatment Center and Translational Medicine Research Center, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing 400030, China.
Ai-Fang JiDepartment of Clinical Laboratory, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi Province, China.
Qi-De BaoDepartment of Oncology, Anyan District Hospital, Anyang 455000, Henan Province, China.
She-Gan GaoDepartment of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Xue-Na HanHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Xin-Min LiDepartment of Pathology, The Maternal and Child Health Care Hospital of Zhengzhou, Zhengzhou 450052, Henan Province, China.
Pei-Nan ChenDepartment of Thoracic Surgery, The Affiliated Cancer Hospital, Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Xue-Ke ZhaoHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Xin SongHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Li-Dong WangHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal squamous cell carcinoma (ESCC) is a cancer with a poor prognosis, characterized by distinct geographical distribution and family clustering.

aimTo investigate if ethnic differences (Han

methodsHere, we sequenced samples from 299 ESCC patients collected from Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, including Han and Kazakh ethnic groups, and performed a genomic comparative analysis of these two ethnic cohorts.

resultsESCC patients of Kazakh ethnicity present with a later age of onset compared to Han. Kazakh patients exhibit a slightly higher tumor mutation burden compared to their Han counterparts. Three genes

conclusionLiving environment and diet are major factors in the development of ESCC. Genomic difference may provide guidance for the formulation of clinical treatment plans for ESCC from different ethnics regions.

Indexed as

Central Asian PeopleEast Asian PeopleEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaAdultAgedAge of OnsetChinaExome SequencingFemaleHumansMaleMiddle AgedMutationPrognosisApolipoprotein B messenger RNA-editing enzyme catalytic polypeptideDietEsophageal squamous cell carcinomaEthnic differenceHanKazakhSingle base substitutions 6Whole-exome sequencing

Identifiers

PMID41479646
PMCPMC12754140

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