Evidence map›Paper›PMID 41479633›Full record

ArticleAnnals of burns and fire disasters2025

Evaluation of Tranexamic Acid for the Reduction of Blood Loss During Burn Surgery in Adults (Tranburn Study).

M Fontaine, O Martin, N Mellati, J C Poupelin, B Farny, S Wiramus, J Lachamp, J Payre, F Ravat, S Gette and 2 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Annals of burns and fire disasters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M FontaineBurn Intensive Care Unit, Saint Joseph Saint Luc Hospital, Lyon, France.
O MartinLyon Pierre Colson Burn Center, Edouard Herriot Hospital, Lyon, France.
N MellatiBurn Intensive Care Unit, Metz-Thionville Regional Hospital, Ars-Laquenexy, France.
J C PoupelinLyon Pierre Colson Burn Center, Edouard Herriot Hospital, Lyon, France.
B FarnyBurn Intensive Care Unit, Saint Joseph Saint Luc Hospital, Lyon, France.
S WiramusDepartment of Anaesthesia and Intensive Care Medicine and Burn Centre, University Hospital of Marseille, La Conception Hospital, Marseille, France.
J LachampDepartment of Anaesthesia and Intensive Care Medicine and Burn Centre, University Hospital of Marseille, La Conception Hospital, Marseille, France.
J PayreBurn Intensive Care Unit, Saint Joseph Saint Luc Hospital, Lyon, France.
F RavatBurn Intensive Care Unit, Saint Joseph Saint Luc Hospital, Lyon, France.
S GetteBurn Intensive Care Unit, Metz-Thionville Regional Hospital, Ars-Laquenexy, France.
D VoulliaumeBurn Intensive Care Unit, Saint Joseph Saint Luc Hospital, Lyon, France.
J LatarjetBurn Intensive Care Unit, Saint Joseph Saint Luc Hospital, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study is the evaluation of the use of tranexamic acid (TXA) for the reduction of blood loss and the use of blood products. We conducted a prospective, multicenter, interventional, randomized, blinded study in 4 burn intensive care units. Patients over 18 years of age with at least 5% body surface area burns scheduled for surgery were included. The treated group received 1g TXA intravenously, then 1g TXA over 8h. The placebo group received saline. Blood loss was calculated using the Mercuriali formula. 121 patients were enrolled. The groups were similar in terms of sex, age, burn etiology, total burn surface area (TBSA), SAPS II and ASA scores, weight, height and estimated total blood volume. The median TBSA was 15% and the median graft size was 1499 cm

Indexed as

blood lossblood product transfusionburn surgeryhemostasistranexamic acid

Identifiers

PMID41479633
PMCPMC12755343

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.