Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health.

Sangam Rajak, Ambuj Shahi, Abhishek Yadav, Pratik Medhe, Rohit A Sinha

Abstract readReview

In one paragraph

Review in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sangam RajakDepartment of System Toxicology, FEST Division, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India.

Ambuj ShahiDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India.

Abhishek YadavDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India.

Pratik MedheDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India.

Rohit A SinhaDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India. anthony.rohit@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as non-alcoholic fatty liver disease, is a major cause of end-stage liver disease worldwide. Numerous studies have demonstrated that the liver is predominantly influenced by environmental and lifestyle risk factors that lead to obesity and diabetes, excessive alcohol consumption, and exposure to environmental pollutants. Microplastics (MPs) are a significant global concern, having been detected in human blood, lungs, kidneys, and liver, and may have deleterious effects on these tissues. Although the effects of MP exposure on the liver have only been partially elucidated, further research is necessary to integrate the direct and extrahepatic effects of MPs on the pathogenesis of MASLD. This review offers a comprehensive analysis of the impact of MPs on hepatic metabolism, including their effects on mitochondrial homeostasis and the endocrine system, with potential implications for the progression of MASLD.

Indexed as

InflammationLipid metabolismLiverMetabolic dysfunction-associated steatotic liver diseaseMicroplastics

Identifiers

PMID41479513

DOI10.4254/wjh.v17.i12.111198

PMCPMC12754402

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.